Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Department of Pathology, Henry Ford Health System, Detroit, Michigan, USA.
Diagn Cytopathol. 2020 Jun;48(6):567-570. doi: 10.1002/dc.24412. Epub 2020 Mar 11.
Glioblastoma is an aggressive primary central nervous system tumor with a dismal prognosis. However, extracranial metastases are extremely rare. Very few cases have been reported in the literature. We present a case of a 64-year-old male with glioblastoma metastatic to a cervical lymph node in which the diagnosis was made on fine needle aspiration cytology (FNAC). The cytomorphologic features of glioblastoma are distinct, with pleomorphic cells in loosely cohesive clusters with prominent nucleoli, coarsely clumped chromatin and cellular processes. We suggest that FNAC, along with clinical history, is a cost effective, safe, and diagnostically accurate method of diagnosing glioblastoma metastases. Cell block is also helpful in establishing the diagnosis.
胶质母细胞瘤是一种侵袭性的原发性中枢神经系统肿瘤，预后不良。然而，颅外转移极为罕见。文献中报道的病例很少。我们报告了一例 64 岁男性患有胶质母细胞瘤转移至颈部淋巴结的病例，该病例的诊断是通过细针穿刺细胞学（FNAC）做出的。胶质母细胞瘤的细胞形态特征明显，具有多形性细胞，松散聚集形成簇状，核仁明显，染色质粗糙聚集，细胞突起明显。我们建议 FNAC 结合临床病史，是一种经济有效、安全且诊断准确的胶质母细胞瘤转移诊断方法。细胞块也有助于确立诊断。
