Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Semin Thromb Hemost. 2020 Mar;46(2):183-188. doi: 10.1055/s-0040-1702169. Epub 2020 Mar 11.
Plasmin generation in trauma patients has wide-ranging effects, from breakdown of clots to remodeling the extracellular matrix. An evolving recognition of plasmin as a critical effector molecule in various inflammatory signals and pathways has rendered the study of plasmin(ogen) and its regulation by upstream activators and downstream targets and inhibitors key to understanding the inflammatory responses to trauma. Tranexamic acid, a widely available lysine analogue medication on the World Health Organization's list of essential medicines, has rapidly become one of the most commonly implemented adjunct treatments for bleeding after traumatic injury in clinical practice. In this article, we review the effects, both anti- and proinflammatory, of tranexamic acid, with a focus on the injured trauma patient.
创伤患者的纤溶酶生成具有广泛的影响，从血栓的分解到细胞外基质的重塑。纤溶酶作为各种炎症信号和途径中的关键效应分子的认识不断发展，使得对纤溶酶（原）及其由上游激活剂和下游靶标和抑制剂调节的研究成为理解创伤后炎症反应的关键。氨甲环酸是世界卫生组织基本药物清单上广泛可用的赖氨酸类似物药物，已迅速成为创伤后出血最常用的辅助治疗方法之一。在本文中，我们综述了氨甲环酸的抗炎和促炎作用，重点关注受伤的创伤患者。
