Electrophysiologic studies on ventricular tachyarrhythmias in a chronic canine infarct model.

The development of a chronic canine infarct model has allowed us to (1) understand better the mechanisms of tachyarrhythmogenesis in infarction; (2) evaluate new antiarrhythmic regimens as well as other antitachycardia therapies, including cryoablation, laser ablation, pacing, and surgical techniques; (3) correlate directly the presence of low-level late potentials with myocardial activation in the presence of delayed and fractionated cardiac electrograms; and (5) evaluate critically our present methods of programmed electrical stimulation.