无毒脂多糖A和内毒素对小鼠抗刚地弓形虫能力的影响。
Effects of nontoxic lipid A and endotoxin on resistance of mice to Toxoplasma gondii.
作者信息
Masihi K N, Ribi E, Lange W, Werner H
机构信息
Robert Koch Institute, Federal Health Office, Berlin, F.R.G.
出版信息
J Biol Response Mod. 1988 Dec;7(6):535-9.
PMID:3216221
Abstract
Mice were administered nontoxic monophosphoryl lipid A (MPL) or refined standard bacterial endotoxin (RSE) prior to, simultaneously with, or after infection with Toxoplasma gondii. MPL and RSE given before or with the toxoplasma infection induced significant resistance. Administration of toxic RSE, but not nontoxic MPL, after the establishment of toxoplasma infection significantly shortened the survival time of mice.
摘要
在感染刚地弓形虫之前、同时或之后，给小鼠施用无毒的单磷酰脂质A（MPL）或精制标准细菌内毒素（RSE）。在弓形虫感染之前或同时给予MPL和RSE可诱导显著的抗性。在弓形虫感染确立后施用有毒的RSE而非无毒的MPL，会显著缩短小鼠的存活时间。
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