State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
Methods Mol Biol. 2020;2131:365-374. doi: 10.1007/978-1-0716-0389-5_21.
Autoantibodies are antibodies against host self-proteins (autoantigens), which play significant roles in homeostasis maintenance and diseases with autoimmune disorders. Numerous papers were published in the past decade on the identification of human autoantigens in different human diseases. However, there is no consensus collection with all the reported autoantigens yet. To address this need, previously we developed a human autoantigen database, AAgAtlas 1.0, by text-mining and manual curation, which collects 1126 autoantigens associated with 1071 human diseases. AAgAtlas 1.0 provides a user-friendly interface to conveniently browse, retrieve, and download human autoantigen genes, their functional annotation, related diseases, and the evidence from the literature. AAgAtlas is freely available online http://biokb.ncpsb.org/aagatlas/ . In this chapter, we make an introduction and provide a guide to the users of AAgAtlas 1.0 database.
自身抗体是针对宿主自身蛋白（自身抗原）的抗体，在维持内稳态和自身免疫性疾病中发挥重要作用。过去十年中，已有大量文献报道了不同人类疾病中的人类自身抗原。然而，目前尚未有一个共识的集合包含所有报道的自身抗原。为了解决这一需求，我们之前通过文本挖掘和人工策展开发了一个人类自身抗原数据库 AAgAtlas 1.0，该数据库收集了与 1071 种人类疾病相关的 1126 种自身抗原。AAgAtlas 1.0 提供了一个用户友好的界面，方便用户浏览、检索和下载人类自身抗原基因、它们的功能注释、相关疾病以及文献中的证据。AAgAtlas 可在网上免费获取：http://biokb.ncpsb.org/aagatlas/。在本章中，我们将对 AAgAtlas 1.0 数据库的用户进行介绍和指导。
