Centre Hospitalier Alpes Léman, Contamine-sur-Arve, France.
Centre Hospitalier de Villefanche sur Saône, Villefranche sur Saône, France.
J Chemother. 2020 Oct;32(6):323-325. doi: 10.1080/1120009X.2020.1734163. Epub 2020 Mar 12.
() infectious endocarditis (IE) is a serious disease that usually requires lengthy treatment with a combination of amoxicillin and gentamicin. Since severe nephrotoxicity can be associated with prolonged administration of gentamicin, the alternative use of daptomycin in combination with amoxicillin can be considered. We present the case of a 51-year-old man that presented an endocarditis on an aortic bicuspidy. Diagnosis of cirrhosis was made simultaneously, and therefore gentamicin was counter-indicated. A combination of amoxicillin 12 g per day and daptomycin 700 mg (10 mg/kg) was administrated, with resolution of clinical, biological and echographic abnormalities, and no relapse after 1 year. In our experience, amoxicillin with daptomycin could be an alternative in case of IE with counter-indication to aminoglycosides.
()感染性心内膜炎（IE）是一种严重的疾病，通常需要联合使用阿莫西林和庆大霉素进行长时间治疗。由于庆大霉素长期使用可能会导致严重的肾毒性，因此可以考虑使用达托霉素联合阿莫西林替代治疗。我们报告了一例 51 岁男性患者，他患有主动脉二叶瓣心内膜炎。同时诊断出肝硬化，因此庆大霉素被禁用。给予阿莫西林 12 g/天和达托霉素 700 mg（10 mg/kg）联合治疗，临床、生物学和超声异常均得到缓解，1 年后无复发。根据我们的经验，在存在氨基糖苷类药物使用禁忌的情况下，阿莫西林联合达托霉素可能是治疗 IE 的一种替代方案。
