Chen Yan, Duan Jing
Clin Lab. 2020 Mar 1;66(3). doi: 10.7754/Clin.Lab.2019.190814.
The current study aims to evaluate the correlation between peripheral blood miR-148a-3p level in patients with liver injury after hepatectomy under general anesthesia with propofol, thereby evaluating whether circulating miR-148a-3p can be used as a biomarker of liver injury after hepatectomy.
One hundred one patients who underwent hepatectomy at the Fourth Hospital of Xi'an were selected. On the first day after operation, peripheral blood was taken to determine the level of miR-148a-3p in peripheral blood. The correlation between circulating miR-148a-3p and liver injury after operation was analyzed using Pearson's correlation assay.
First, our data showed that the level of miR-148a-3p was increased in the peripheral blood of patients after hepatectomy. The amount of bleeding was significantly correlated with the increase of ALT, AST, and miR-148a-3p. Moreover, the level of miR-148a-3p was significantly correlated with alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Further analysis showed that intraoperative propofol dosage was correlated with ALT, AST, and miR-148a-3p after hepatectomy.
MiR-148a-3p may be sensitive to ischemic and traumatic liver injury and may be a marker of liver injury after hepatectomy under general anesthesia with propofol.
本研究旨在评估全身麻醉下丙泊酚肝切除术后患者外周血miR-148a-3p水平之间的相关性，从而评估循环miR-148a-3p是否可作为肝切除术后肝损伤的生物标志物。
选取西安市第四医院101例行肝切除术的患者。术后第一天采集外周血，测定外周血中miR-148a-3p水平。采用Pearson相关分析方法分析循环miR-148a-3p与术后肝损伤的相关性。
首先，我们的数据显示肝切除术后患者外周血中miR-148a-3p水平升高。出血量与ALT、AST和miR-148a-3p的升高显著相关。此外，miR-148a-3p水平与丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）显著相关。进一步分析表明，术中丙泊酚用量与肝切除术后ALT、AST和miR-148a-3p相关。
MiR-148a-3p可能对缺血性和创伤性肝损伤敏感，可能是全身麻醉下丙泊酚肝切除术后肝损伤的标志物。
