Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga, Lithuania.
National Obsessive Compulsive Disorders Specialist Service, Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, UK.
Int J Psychiatry Clin Pract. 2020 Jun;24(2):116-119. doi: 10.1080/13651501.2019.1666148. Epub 2020 Mar 12.
This study aims at identifying associations between cognitive function and suicidal ideation in the sample of patients with anxiety and mood disorders (AMD). In sum, 186 (age = 39 ± 12.3 years; 142 [76.3%] females) patients with AMD were enrolled in the study. Assessment included evaluation of socio-demographic information, medication use, anxiety and depression symptoms. Cognitive tests included measures of psychomotor performance and incidental learning using the Digit Symbol Test. Trail Making Tests respectively measured perceptual speed, task-switching and executive control. Additionally, 21 patients completed tests from the Cambridge Automated Neuropsychological Test Battery measuring set shifting (Interdimensional/extradimensional set-shift), executive planning (Stockings of Cambridge), and decision making (Cambridge Gamble Task [CGT]). Almost half (45.0%, = 86) of the study sample patients had experienced suicidal ideations. In multivariable regression analysis, suicidal ideation was associated with a greater overall proportion of bet and risk taking on the CGT task ( = 0.726, = .010 and = 0.634, = .019), when controlling for socio-demographic characteristics, medication use, anxiety and depression symptoms. Outpatients with AMD and suicidal ideation could be distinguished by the presence of cognitive deficits in the executive function domain, particularly in impulse-control and risk taking.
本研究旨在确定焦虑和心境障碍（AMD）患者样本中认知功能与自杀意念之间的关联。共有 186 名（年龄=39±12.3 岁；142 名[76.3%]女性）AMD 患者入组本研究。评估包括社会人口统计学信息、药物使用、焦虑和抑郁症状的评估。认知测试包括使用数字符号测试评估心理运动表现和偶然学习。连线测试分别测量感知速度、任务转换和执行控制。此外，21 名患者完成了剑桥自动化神经心理测试电池中的测试，用于测量转换能力（维度间/额外维度转换）、执行计划（剑桥套圈测试）和决策（剑桥赌博任务 [CGT]）。研究样本中近一半（45.0%，=86）的患者有过自杀意念。在多变量回归分析中，当控制社会人口统计学特征、药物使用、焦虑和抑郁症状时，自杀意念与 CGT 任务中更大的总体打赌和冒险倾向相关（=0.726，=0.010 和=0.634，=0.019）。有自杀意念的 AMD 门诊患者可以通过执行功能领域的认知缺陷来区分，特别是冲动控制和冒险倾向。
