School of Science, Monash University Malaysia Campus, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor, Malaysia.
Curr Med Chem. 2021;28(9):1716-1730. doi: 10.2174/0929867327666200312114223.
Alzheimer's disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently, there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Hence, antihypertensives were postulated to be beneficial in managing AD. Four classes of antihypertensives, as well as their potential limitations and prospects in being utilised as AD therapeutics, were discussed in this review.
阿尔茨海默病（AD）是一种神经退行性疾病，已经影响了全球数百万人。然而，目前尚无治愈该病的方法。市场上现有的 AD 药物只能对症治疗疾病，且效果通常是短期的。因此，需要寻找其他 AD 治疗方法。本文献综述旨在探讨将抗高血压药重新用于治疗 AD 的潜力。中年高血压不仅被认为是 AD 的一个危险因素，而且其与 AD 的关系也已得到充分证实。因此，人们推测抗高血压药对 AD 的治疗有益。本综述讨论了四类抗高血压药及其作为 AD 治疗药物的潜在局限性和前景。
