Liu Wenying, Zhao Yaya, Rao Yutong, Wu Zijing, Peng Yun, Gong Lianggeng
Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiangxi Provincial Key Laboratory of Intelligent Medical Imaging, Nanchang, China.
Front Neurol. 2025 Apr 28;16:1514054. doi: 10.3389/fneur.2025.1514054. eCollection 2025.
Alzheimer's disease (AD) is a neurodegenerative disease that imposes a heavy burden on patients and their families. Hypertension is an important risk factor for AD, but the specific mechanism of its impact is still unclear. This study thus aimed to analyze the relationship and trend changes between AD and hypertension through bibliometric methods.
Literature on AD and hypertension was retrieved from the Web of Science Core Collection (WoSCC) database between 2004 and 2023. Data regarding countries, institutions, authors and journals were sourced from WoSCC. CiteSpace and VOSviewer were used for data visualization, including author collaboration, timelines view of references, reference bursts and overlay visualization maps of keywords. Excel 2018 software was used for the statistical analysis.
A total of 1,833 publications were ultimately included. From 2004 to 2023, the number of publications per year basically showed an increasing trend. The United States (United States) not only had the largest output of publications and the highest H-index but also had the seven highest frequencies of publication institutions. Kehoe, Patrick ranked first with the most articles among 9,330 authors. The journal with the most published articles was the Journal of Alzheimer's Disease. Reference analysis revealed a hotspot in the exploration of the pathophysiological association between AD and hypertension. Second, the treatment effects and potential risks of antihypertensive drugs (AHDs) on AD are also the focus of research. Researchers have carried out a series of studies ranging from basic research to clinical research on AHDs for the treatment of AD. Finally, personalized treatment strategies will also become one of the hotspots of future research. Controlling hypertension through lifestyle changes and medication interventions in AD patients is a promising strategy. The analysis of keywords revealed that "amyloid deposition," "preeclampsia," "Corona Virus Disease 2019 (COVID-19)" and "biomarkers" have been research hotspots in recent years.
By analyzing the references and keywords, we summarized the hot topics and research trends in this field. These findings provide useful information for researchers to explore the relationship between hypertension and AD further, with the hope of providing more effective treatments for AD patients to delay disease progression and improve quality of life.
阿尔茨海默病（AD）是一种给患者及其家庭带来沉重负担的神经退行性疾病。高血压是AD的一个重要风险因素，但其具体影响机制仍不清楚。因此，本研究旨在通过文献计量学方法分析AD与高血压之间的关系及趋势变化。
从2004年至2023年的科学网核心合集（WoSCC）数据库中检索关于AD和高血压的文献。有关国家、机构、作者和期刊的数据均来自WoSCC。使用CiteSpace和VOSviewer进行数据可视化，包括作者合作、参考文献的时间线视图、参考文献爆发以及关键词叠加可视化地图。使用Excel 2018软件进行统计分析。
最终共纳入1833篇出版物。2004年至2023年，每年的出版物数量基本呈上升趋势。美国不仅出版物产出量最大、H指数最高，而且有7个出版物机构的发文频率最高。在9330位作者中，基奥·帕特里克发表的文章数量最多，排名第一。发表文章最多的期刊是《阿尔茨海默病杂志》。参考文献分析揭示了AD与高血压之间病理生理关联探索的一个热点。其次，抗高血压药物（AHDs）对AD的治疗效果和潜在风险也是研究重点。研究人员针对AHDs治疗AD开展了一系列从基础研究到临床研究的工作。最后，个性化治疗策略也将成为未来研究的热点之一。通过生活方式改变和药物干预控制AD患者的高血压是一种有前景的策略。关键词分析表明，“淀粉样蛋白沉积”“先兆子痫”“2019冠状病毒病（COVID-19）”和“生物标志物”是近年来的研究热点。
通过分析参考文献和关键词，我们总结了该领域的热点话题和研究趋势。这些发现为研究人员进一步探索高血压与AD之间的关系提供了有用信息，有望为AD患者提供更有效的治疗方法，以延缓疾病进展并提高生活质量。
