外用糖皮质激素与三氯乙酸联合治疗疣状扁平苔藓的疗效观察
[Successful combination of topical corticosteroids and trichloroacetic acid for the treatment of verrucous lichen planus].
作者信息
Lahlou F, El Fatoiki F, Hali F, Chiheb S
机构信息
Service de dermatologie-vénéréologie, CHU Ibn Rochd Casablanca, Casablanca, Maroc.
Service de dermatologie-vénéréologie, CHU Ibn Rochd Casablanca, Casablanca, Maroc.
出版信息
Ann Dermatol Venereol. 2020 Apr;147(4):293-297. doi: 10.1016/j.annder.2019.10.025. Epub 2020 Mar 9.
BACKGROUND
Verrucous or hypertrophic lichen planus is a chronic inflammatory skin disease characterized by extremely pruritic thick hyperkeratotic plaques and is resistant to topical treatment.
PATIENTS AND METHODS
Herein, we report three clinical cases of hypertrophic lichen planus successfully treated with a combination of topical steroids daily in occlusion and trichloroacetic acid (TCA) 50% with peeling every week.
DISCUSSION
TCA is involved in regulating inflammation and scarring. Through its keratolytic properties it enhances the efficacy of topical steroids, whose action is hindered by hyperkeratosis.
CONCLUSION
The combination of TCA and topical steroids offers a good alternative for the treatment of hypertrophic lichen planus.
背景
疣状或肥厚性扁平苔藓是一种慢性炎症性皮肤病，其特征为极度瘙痒的厚角质化斑块，且对局部治疗有抵抗性。
患者与方法
在此，我们报告三例肥厚性扁平苔藓的临床病例，通过每日外用类固醇封包治疗与每周一次50%三氯乙酸（TCA）剥脱联合治疗，取得了成功。
讨论
三氯乙酸参与调节炎症和瘢痕形成。通过其角质溶解特性，它增强了外用类固醇的疗效，而角质增生会阻碍外用类固醇的作用。
结论
三氯乙酸与外用类固醇联合使用为肥厚性扁平苔藓的治疗提供了一种良好的替代方案。
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