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阿齐沙坦美多昔酯

Azilsartan medoxomil.

作者信息

Al-Majed Abdulrahman A, Bakheit Ahmed H H, Al-Muhsin Ali, Al-Kahtani Hamad M, Abdelhameed Ali S

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.

出版信息

Profiles Drug Subst Excip Relat Methodol. 2020;45:1-39. doi: 10.1016/bs.podrm.2019.10.001. Epub 2019 Dec 6.

Abstract

Azilsartan is used for treatment of the high blood pressure (hypertension). Reducing high blood pressure enables avoid strokes, heart attacks and problems of kidneys. Azilsartan comes under the name angiotensin receptor blocker (ARBs) as a class of drugs. It acts by relaxing blood vessels to make it easier for blood to flow. Azilsartan Medoxomil's a comprehensive profile containing the description, formulae, Elemental Analysis, Uses and application. Furthermore, methods and schemes are outlined for the preparation of the drug substance. The physical properties of the medication include constant of ionization, solubility, X-ray powder diffraction pattern, differential scanning calorimetry, thermal conduct and spectroscopic studies are investigated. The methods employed in bulk medicines and/or in pharmaceutical formulations to analyze the drug substance include spectrophotometric, electrochemical and the chromatographic methods. Other studies on this drug substance include drug stability, Pharmaceutical Applications, Mechanism of Action, Pharmacodynamics, and a Dosing Information are reviewed. At the end of this profile, there are more than sixty references were listed.

摘要

阿齐沙坦用于治疗高血压。降低高血压可预防中风、心脏病发作和肾脏问题。阿齐沙坦属于血管紧张素受体阻滞剂(ARB)类药物。它通过舒张血管起作用,使血液流动更容易。阿齐沙坦美洛昔酯有一份全面的资料,包含描述、配方、元素分析、用途及应用。此外,还概述了药物制备的方法和方案。该药物的物理性质包括电离常数、溶解度、X射线粉末衍射图谱、差示扫描量热法、热导率以及光谱研究。用于分析原料药的大宗药品和/或药物制剂中的方法包括分光光度法、电化学法和色谱法。对该原料药的其他研究包括药物稳定性、药物应用、作用机制、药效学以及给药信息等方面均有综述。在这份资料末尾,列出了六十多篇参考文献。

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