Service de pharmacologie médicale et clinique, faculté de médecine, CIC 1436, CHU et université Paul Sabatier - Toulouse 3, 31000 Toulouse, France.
Therapie. 2020 Apr;75(2):215-220. doi: 10.1016/j.therap.2020.02.013. Epub 2020 Feb 13.
Large electronic health records database available at a national level offer great opportunity for research in rare diseases and orphan drugs. Methods and data used in pharmacoepidemiology present a great potential for epidemiology, drug utilization studies, drug safety, drug effectiveness and pharmacoeconomics. This review presents the different sources of data in Europe, with a special focus on the French situation, with the recent implementation of SNDS (système national des données de santé [French national health data wharehouse]). Some examples are given. Development of rigorous and innovative methods must be encouraged in the future.
大型电子健康记录数据库在国家层面上为罕见病和孤儿药的研究提供了巨大的机会。药物流行病学中使用的方法和数据为流行病学、药物利用研究、药物安全、药物疗效和药物经济学提供了巨大的潜力。本文综述了欧洲不同的数据来源，特别关注了法国的情况，法国最近实施了 SNDS（système national des données de santé [French national health data wharehouse]）。本文提供了一些示例。未来必须鼓励开发严格和创新的方法。
