猪流感病毒感染引起的肺部炎症反应受 DAP12 和巨噬细胞 M1 和 M2 表型的调节。
Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes.
机构信息
Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India.
Food Animal Health Research Program, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, USA.
出版信息
Cell Immunol. 2020 Jun;352:104078. doi: 10.1016/j.cellimm.2020.104078. Epub 2020 Feb 21.
We delineated the expression of DAP12 (DNAX-Activating Protein) and its associated receptors, TREM-1, TREM-2 and MDL-1 in pig alveolar monocyte/macrophages (AMM) that have attained M1 or M2 phenotypes. Pig AMM stimulated in vitro with IFN-γ and IL-4 induced the expression of M1 (TNFα and iNOS) and M2 (ARG1 and no MMR) phenotypic markers, respectively. In influenza virus infected pigs at seven days post-infection, in addition to substantial modulations in the M1 and M2 markers expression, DAP12, TREM-1 and MDL-1 were downregulated in AMM. Thus, DAP12 signaling promoted the anti-inflammatory pathway in AMM of influenza virus infected pigs.
我们描绘了 DAP12（DNAX 激活蛋白）及其相关受体 TREM-1、TREM-2 和 MDL-1 在已获得 M1 或 M2 表型的猪肺泡单核细胞/巨噬细胞（AMM）中的表达。体外用 IFN-γ 和 IL-4 刺激猪 AMM 分别诱导 M1（TNFα 和 iNOS）和 M2（ARG1 和无 MMR）表型标志物的表达。在感染流感病毒后的第 7 天，除了 M1 和 M2 标志物表达的大量调节外，DAP12、TREM-1 和 MDL-1 在 AMM 中下调。因此，DAP12 信号促进了感染流感病毒的猪 AMM 中的抗炎途径。
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