基于人群的粪便免疫化学检测筛查计划中结直肠癌间隔期的比例发病情况。
Proportional incidence of interval colorectal cancer in a large population-based faecal immunochemical test screening programme.
机构信息
Romagna Cancer Registry, Romagna Cancer Institute, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST, IRCCS, Meldola, Italy.
Romagna Cancer Registry, Romagna Cancer Institute, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST, IRCCS, Meldola, Italy.
出版信息
Dig Liver Dis. 2020 Apr;52(4):452-456. doi: 10.1016/j.dld.2020.02.007. Epub 2020 Mar 9.
BACKGROUND
The European guidelines for quality assurance in colorectal cancer (CRC) screening recommend that interval cancer rate be expressed as a proportion of background incidence rate.
AIM
To determine the crude and adjusted proportional incidence of interval CRC in an Italian regional two-yearly faecal immunochemical test (FIT) screening programme.
METHODS
The programme (year of implementation, 2005) is targeted at over 1,000,000 people aged 50-69 years. The test is a one-sample OC-Sensor (Eiken Chemical Co., Tokyo, Japan). The study covered one-third of the regional area. Excerpts of 434,295 eligible negative FIT records dated 2005-2012 from 193,193 subjects were retrieved from the regional CRC screening data warehouse. By 31 December 2013, the cohort accumulated 198,302 man-years and 235,370 woman-years. Interval CRCs were identified by record-linkage with the local population-based cancer registry. Their number was divided by the expected number, estimated with age-period-cohort models, to obtain the proportional incidence.
RESULTS
The proportional incidence of interval CRC for men and women was, respectively, 0.06 (95% confidence interval (CI), 0.04-0.09) and 0.17 (95% CI, 0.13-0.23) in the first interval year, and 0.21 (95% CI, 0.16-0.26) and 0.28 (95% CI, 0.22-0.36) in the second year.
CONCLUSIONS
The results were acceptable and in line with previous studies.
背景
欧洲结直肠癌（CRC）筛查质量保证指南建议将间期癌的发生率表示为背景发生率的比例。
目的
确定意大利区域性两年一次粪便免疫化学试验（FIT）筛查计划中间期 CRC 的粗发生率和校正比例发生率。
方法
该计划（实施年份为 2005 年）针对 100 多万 50-69 岁人群。该检测采用 OC-Sensor 单样本检测（日本东京荣研化学株式会社）。研究覆盖了该地区的三分之一。从 193193 名受试者中提取了 2005-2012 年日期的 434295 份合格阴性 FIT 记录摘录，来自区域 CRC 筛查数据仓库。截至 2013 年 12 月 31 日，该队列累积了 198302 人年和 235370 人年。通过与当地基于人群的癌症登记处的记录链接，确定了间期 CRC 的数量。将它们的数量除以年龄-时期-队列模型估计的预期数量，以获得比例发生率。
结果
男性和女性第一间隔年的间期 CRC 比例发生率分别为 0.06（95%置信区间（CI），0.04-0.09）和 0.17（95% CI，0.13-0.23），第二年分别为 0.21（95% CI，0.16-0.26）和 0.28（95% CI，0.22-0.36）。
结论
结果是可以接受的，与之前的研究一致。
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