Panneman E L, Coric D, Tran L M D, de Vries-Knoppert W A E J, Petzold A
Expertisecentre Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, Amsterdam UMC, Amsterdam, The Netherlands.
MS Centre Amsterdam, Department of Neurology, Amsterdam UMC, Amsterdam, The Netherlands.
Neuroophthalmology. 2019 May 27;43(6):382-390. doi: 10.1080/01658107.2019.1599027. eCollection 2019 Dec.
In the visual pathway of patients with multiple sclerosis (MS), the inner nuclear layer (INL) of the retina is a tight barrier for retrograde trans-synaptic degeneration. In this observational, retrospective cross-sectional study, segmented macular spectral domain optical coherence tomography (OCT) volume scans were reviewed to investigate if this observation also holds true for anterograde trans-synaptic degeneration. Significant thinning was found in all retinal layers in patients with outer retinal diseases compared with the healthy controls, while there was no significant attenuation of the outer retina in patients with MS. In contrast to the tight barrier function observed with retrograde trans-synaptic degeneration, the INL appears to be more permissive for the propagation of anterograde trans-synaptic degeneration. We speculate that this may be due to the size of the area affected and be explained by convergence and divergence of axons within the retinal layers. These findings are likely relevant to future restorative stem cell treatment of the outer retinal layers, as time may matter.
在多发性硬化症（MS）患者的视觉通路中，视网膜内核层（INL）是逆行跨突触变性的紧密屏障。在这项观察性、回顾性横断面研究中，对分段黄斑光谱域光学相干断层扫描（OCT）容积扫描进行了回顾，以研究这一观察结果对于顺行跨突触变性是否也成立。与健康对照组相比，外层视网膜疾病患者的所有视网膜层均出现显著变薄，而MS患者的外层视网膜没有明显变薄。与逆行跨突触变性所观察到的紧密屏障功能相反，INL似乎对顺行跨突触变性的传播更为宽松。我们推测，这可能是由于受影响区域的大小所致，并可以通过视网膜层内轴突的汇聚和发散来解释。随着时间可能至关重要，这些发现可能与未来外层视网膜层的恢复性干细胞治疗相关。
