Department of Otolaryngology, Huazhong University of Science and Technology, Wuhan, 430022, China.
Physical Examination Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Curr Med Sci. 2020 Feb;40(1):168-171. doi: 10.1007/s11596-020-2160-x. Epub 2020 Mar 13.
The study investigated the distribution of Epstein-Barr virus (EBV) EA-IgA, VCA-IgA, and EBVNA-IgG antibodies in a local population of Wuhan, China. Chemiluminescence immunoassay (CLIA) was used to detect EBV EA-IgA, VCA-IgA, and EBVNA-IgG antibodies in 972 subjects undergoing physical examination in Wuhan, and the results were analyzed. The detection rate of EBV was positively correlated with age. In the 972 cases, there was significant difference between different genders in the positive rate of VCA-IgA and EBVNA-IgG. Moreover, the positive rate of VCA-IgA and EBVNA-IgG was higher in men ≥ 60 years old than in those < 60 but no significant differences were found in three antibodies among various age groups. Our results suggested that the EBV infection should be intensively monitored in elderly people in Wuhan.
本研究调查了武汉地区人群中 Epstein-Barr 病毒 (EBV) EA-IgA、VCA-IgA 和 EBVNA-IgG 抗体的分布。采用化学发光免疫分析法 (CLIA) 检测了武汉 972 例体检人群的 EBV EA-IgA、VCA-IgA 和 EBVNA-IgG 抗体，并对结果进行了分析。EBV 的检出率与年龄呈正相关。在 972 例患者中，VCA-IgA 和 EBVNA-IgG 的阳性率在不同性别间存在显著差异，且男性≥60 岁者 VCA-IgA 和 EBVNA-IgG 的阳性率高于<60 岁者，但三组抗体在各年龄段间的阳性率差异均无统计学意义。我们的研究结果提示，武汉地区老年人应加强 EBV 感染的监测。
