Mukherjee A B, Weinstein M E
Department of Biological Sciences, Fordham University, Bronx, NY 10458.
Mech Ageing Dev. 1988 Oct;45(1):59-64. doi: 10.1016/0047-6374(88)90019-x.
The sequence of centromere separation of mitotic chromosomes derived from lymphocytes of 17 individuals of various ages was studied. A comparison of the mean CSI (centromeric separation index) values for individual chromosomes in the complement indicated a significant difference between the older and the younger subjects only with regard to the chromosome nos. 6, 11, and 19 in both sexes and the X chromosome exclusively in the female. With age, chromosome no. 6 in both males and females and the X chromosome in females showed premature centromeric separation whereas chromosome nos. 11 and 19 in both males and females displayed delayed centromeric separation. Our study, therefore, indicates that changes in the sequence of centromeric separation of certain chromosomes do occur in lymphocytes during chronological aging in humans.
研究了来自不同年龄的17名个体淋巴细胞的有丝分裂染色体着丝粒分离序列。对互补体中单个染色体的平均CSI（着丝粒分离指数）值进行比较，结果表明，仅在6号、11号和19号染色体以及仅在女性中的X染色体方面，老年受试者和年轻受试者之间存在显著差异。随着年龄的增长，男性和女性的6号染色体以及女性的X染色体显示着丝粒过早分离，而男性和女性的11号和19号染色体则显示着丝粒分离延迟。因此，我们的研究表明，在人类按时间顺序衰老过程中，淋巴细胞中某些染色体的着丝粒分离序列确实会发生变化。
