Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
College of Veterinary Medicine, The University of Illinois at Urbana-Champaign, Urbana, Illinois 61802; formerly in the Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, The University of Missouri, Columbia, Missouri 65211.
Health Phys. 2020 Jun;118(6):702-710. doi: 10.1097/HP.0000000000001222.
The treatment of pets, service animals, and pre-clinical research subjects with radionuclides raises concern for the safety of the people who interact with the animals after their treatment. Three treatments of skeletal conditions in dogs are considered in this study: Sm-1,4,7,10-tetraazacylcododecanetetramethylenephosphonic acid, which is a bone-seeking radiopharmaceutical; unencapsulated Y permanent interstitial implants, which are sometimes called "liquid brachytherapy"; and Sn radiosynoviorthesis, which is also called radiosynovectomy. External exposure rate readings of the Sm and Sn treatments, and Monte Carlo simulations of Sn at a distance of 1 m and of all three in direct contact with tissue were analyzed for doses. Dogs that have received any of these treatments using typically administered activities may be released from radiation safety isolation immediately after treatment from the standpoint of external exposure. People should avoid prolonged close proximity, such as sleeping with a treated dog, for three weeks following an Y interstitial implant or for a month following Sn radiosynoviorthesis. No such avoidance is necessary after treatment with Sm-1,4,7,10-tetraazacylcododecanetetramethylenephosphonic acid.
放射性核素治疗宠物、服务动物和临床前研究动物引起了人们对与这些动物接触的人的安全性的关注。本研究考虑了三种治疗犬骨骼疾病的方法：Sm-1,4,7,10-四氮杂环十四烷四甲基亚膦酸，这是一种亲骨性放射性药物；未封装的 Y 永久间质植入物，有时称为“液体近距离放射治疗”；以及 Sn 放射性滑膜切除术，也称为放射性滑膜切除术。对 Sm 和 Sn 治疗的外照射率读数以及 1 m 处 Sn 的蒙特卡罗模拟和所有三种直接与组织接触的情况进行了剂量分析。从外照射的角度来看，接受这些治疗的狗，其接受的通常剂量的放射性核素治疗后，可以立即从辐射安全隔离中释放。在接受 Y 间质植入物治疗后，人们应避免三周内与受治疗的狗近距离接触，例如与狗同睡，或者在接受 Sn 放射性滑膜切除术治疗后一个月内避免这种情况。而在接受 Sm-1,4,7,10-四氮杂环十四烷四甲基亚膦酸治疗后，不需要这种回避。
