Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Nigeria.
Department of Agriculture Economics and Extension service, University of Benin, Benin City, Nigeria.
Int J Gynaecol Obstet. 2020 Jun;149(3):354-358. doi: 10.1002/ijgo.13142. Epub 2020 Apr 3.
To determine the serum calcium-magnesium ratio in pre-eclampsia and compare with normotensives.
A case-control study was conducted in a tertiary hospital between October 2017 and March 2018 among 81 pregnant women (27 cases and 54 controls matched for age, gestational age, and parity). An interviewer-administered questionnaire was used to obtain data on demography/clinical history. Venous blood was collected without stasis and sent for biochemical analysis. Statistical analysis used IBM SPSS 21.0.
The levels of serum Ca (7.73 + 1.24 vs 9.17 + 0.77; P<0.001), Ca -Mg ratio (3.36 + 0.60 vs 3.83 + 0.41; P=0.001), and Mg (2.35 + 0.35 vs 2.41 + 0.16; P=0.469) were lower among cases. Serum Ca level correlated negatively with systolic (r=0.45, P=0.05) and diastolic blood pressure (r=0.50, P=0.010) among the cases. Hypocalcemia was a risk factor (adjusted odds ratio [AOR] 7.63, 95% confidence interval [CI] 1.64-35.37) while social classes 2 and 3 were protective factors (AOR 0.01, 95% CI 0.00-0.46 and AOR 0.01, 95% CI 0.00-0.24, respectively) against pre-eclampsia.
The result of this research supported the implication of micronutrients in pre-eclampsia and may help to understand the pathophysiological process of pre-eclampsia. It will also help to establish and enhance existing preventive strategies for the condition. The recommendation by WHO on calcium supplementation in pregnancy as a step in preventing the occurrence of pre-eclampsia should be practiced.
测定子痫前期患者血清钙镁比值，并与血压正常孕妇进行比较。
采用病例对照研究，于 2017 年 10 月至 2018 年 3 月在一家三级医院中进行，共纳入 81 名孕妇（27 例病例和 54 例年龄、孕周和产次匹配的对照）。采用问卷调查收集人口统计学/临床病史数据。采集无淤滞的静脉血进行生化分析。统计分析采用 IBM SPSS 21.0。
病例组血清 Ca（7.73±1.24 比 9.17±0.77；P＜0.001）、Ca-Mg 比值（3.36±0.60 比 3.83±0.41；P=0.001）和 Mg（2.35±0.35 比 2.41±0.16；P=0.469）水平较低。病例组血清 Ca 水平与收缩压（r=0.45，P=0.05）和舒张压（r=0.50，P=0.010）呈负相关。低钙血症是子痫前期的危险因素（校正优势比[OR] 7.63，95%置信区间[CI] 1.64-35.37），而社会阶层 2 和 3 是子痫前期的保护因素（OR 0.01，95%CI 0.00-0.46 和 OR 0.01，95%CI 0.00-0.24）。
本研究结果支持微量营养素与子痫前期的关系，并可能有助于了解子痫前期的病理生理过程。它还将有助于建立和加强现有的预防策略。应实践世卫组织关于妊娠期间补充钙作为预防子痫前期发生措施的建议。
