College of Medicine and Health, Lishui University, Lishui, Zhejiang, China; and.
Chengxi Primary School, Lishui, Zhejiang, China.
J Cardiovasc Pharmacol. 2020 Jun;75(6):596-602. doi: 10.1097/FJC.0000000000000823.
Chrysin (CH) is the main ingredient of many medicinal plants. Our previous study showed that CH could suppress hypoxia-induced pulmonary arterial smooth muscle cells proliferation and alleviate chronic hypoxia-induced pulmonary hypertension by targeting store-operated Ca entry (SOCE)-[Ca]i pathway. In this study, we investigated the effect of CH on monocrotaline-induced pulmonary hypertension (MCTPH) and the mechanism behind it. Results show that, in MCTPH model rats, (1) CH significantly reduced the enhancement of right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling; (2) CH markedly suppressed the promotion of SOCE and [Ca]i in pulmonary arterial smooth muscle cells; and (3) CH obviously inhibited the MCT-upregulated proliferating cell nuclear antigen, TRPC1, TRPC4, and TRPC6 expression in distal pulmonary arteries. These results demonstrate that CH likely alleviates MCTPH by targeting TRPC1,4,6-SOCE-[Ca]i pathway.
白杨素（CH）是许多药用植物的主要成分。我们之前的研究表明，CH 通过靶向储存操作型钙内流（SOCE）-[Ca]i 通路，可抑制低氧诱导的肺动脉平滑肌细胞增殖并缓解慢性低氧诱导的肺动脉高压。在这项研究中，我们研究了 CH 对野百合碱诱导的肺动脉高压（MCTPH）的作用及其机制。结果表明，在 MCTPH 模型大鼠中：（1）CH 显著降低了右心室压力、右心室肥厚和肺血管重构的增强；（2）CH 明显抑制了肺动脉平滑肌细胞中 SOCE 和 [Ca]i 的促进作用；（3）CH 明显抑制了 MCT 上调的增殖细胞核抗原、TRPC1、TRPC4 和 TRPC6 在远端肺血管中的表达。这些结果表明，CH 可能通过靶向 TRPC1、4、6-SOCE-[Ca]i 通路来缓解 MCTPH。
