Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.
Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Exerc Sport Sci Rev. 2020 Apr;48(2):74-82. doi: 10.1249/JES.0000000000000219.
Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.
下丘脑的前阿黑皮素原（POMC）神经元是能量平衡的关键感觉神经元。碱性螺旋-环-螺旋转录因子 NHLH2 在 POMC 神经元中表达，而 Nhlh2 敲除小鼠表现出成年起病的肥胖症和低运动行为。有证据表明，POMC 神经元内的 NHLH2 转录活性对于维持自发活动和强制运动的动机至关重要。
