Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Mattel Children's Hospital at UCLA, Los Angeles, California.
Division of General Internal Medicine and Health Services Research, Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California.
Am J Perinatol. 2021 Aug;38(S 01):e33-e38. doi: 10.1055/s-0040-1705136. Epub 2020 Mar 13.
This study aimed to investigate growth among neonates with gastrointestinal disorders.
Inclusion criteria included neonates with gastroschisis, omphalocele, intestinal atresia, tracheoesophageal fistula, Hirschsprung's disease, malabsorption disorders, congenital diaphragmatic hernia, and imperforate anus born between 2010 and 2018. Anthropometrics were collected for the first 30 months, and a subgroup analysis was performed for gastroschisis infants.
In 61 subjects, 13% developed severe growth failure within the first month. One-, four-, and nine-month weight and length -scores were less than birth weight in all infants ( < 0.05). In infants with gastroschisis, a similar pattern was observed for weight -scores only ( < 0.05). From birth to 15 months, head circumference -score increased over time in all infants ( = 0.001), while in gastroschisis infants, weight, length, and head circumference -scores increased over time ( < 0.05).
In a cohort of infants with gastrointestinal disorders, growth failure was followed by catch-up growth.
本研究旨在探讨胃肠道疾病新生儿的生长情况。
纳入标准为 2010 年至 2018 年间出生的患有腹裂、脐膨出、肠闭锁、食管气管瘘、先天性巨结肠、吸收不良综合征、先天性膈疝和肛门闭锁的新生儿。在最初的 30 个月中收集人体测量学数据，并对腹裂患儿进行亚组分析。
在 61 名患儿中，有 13%的患儿在第一个月内出现严重生长发育迟缓。所有患儿的 1 个月、4 个月和 9 个月体重和身长评分均低于出生体重（<0.05）。在腹裂患儿中，仅体重评分也呈现类似模式（<0.05）。从出生到 15 个月，所有患儿的头围评分随时间增加（=0.001），而在腹裂患儿中，体重、身长和头围评分随时间增加（<0.05）。
在患有胃肠道疾病的患儿队列中，生长迟缓后会出现追赶性生长。
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