雷公藤红素通过抑制 CXCR4 相关信号通路及体内抑制肿瘤生长对肝癌的潜在抗癌作用。
Potential Anticancer Effect of Celastrol on Hepatocellular Carcinoma by Suppressing CXCR4-related Signal and Impeding Tumor Growth in Vivo.
机构信息
Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
出版信息
Arch Med Res. 2020 May;51(4):297-302. doi: 10.1016/j.arcmed.2020.03.001. Epub 2020 Mar 10.
BACKGROUND
Potential agents that can effectively treat hepatocellular carcinoma (HCC) are being continuously explored.
METHODS
Celastrol extracted from roots of an ancient Chinese herb, Tripterygium wilfordii (Thunder god vine), has been identified as a potential anti-tumor agent. In this study, the molecular mechanisms underlying the action of celastrol on cell proliferation and chemokine CXCR4-related signal pathway associated with tumor growth were investigated.
RESULTS
The CXCR4 expression was diminished by celastrol treatment in a dose-dependent manner, and its downstream associated pathways, including PI3K and Akt were also downregulated. Celastrol also significantly attenuated proliferation and migration ability of HCC cells, and induced cell apoptosis in vitro. Additionally, significant inhibition of HCC growth was observed in the celastrol-treated group as compared with the control group in vivo as well.
CONCLUSION
Celastrol is capable of attenuating cell proliferation and inducing apoptosis, leading to inhibition of HCC growth through the suppression of CXCR4-related signal pathway.
背景
目前正在不断探索能够有效治疗肝细胞癌（HCC）的潜在药物。
方法
从雷公藤的根部提取的雷公藤红素已被确定为一种潜在的抗肿瘤药物。本研究旨在探讨雷公藤红素对细胞增殖和与肿瘤生长相关的趋化因子 CXCR4 相关信号通路的作用机制。
结果
雷公藤红素处理呈剂量依赖性降低 CXCR4 的表达，其下游相关通路，包括 PI3K 和 Akt 也被下调。雷公藤红素还显著减弱 HCC 细胞的增殖和迁移能力，并在体外诱导细胞凋亡。此外，与对照组相比，雷公藤红素处理组在体内也显著抑制 HCC 的生长。
结论
雷公藤红素能够通过抑制 CXCR4 相关信号通路，减弱细胞增殖并诱导细胞凋亡，从而抑制 HCC 的生长。
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