Michalová K, Musilová J, Koudelová Z, Placerová J, Matuchová L
3rd Medical Department, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
Neoplasma. 1988;35(5):571-81.
A total of 122 patients with chronic myeloid leukemia (CML) were cytogenetically examined. At the first cytogenetic examination 68 of them were in chronic phase (CP) and 54 in blastic phase (BP) of the disease. The mean age of the whole group was 44.8 +/- 15.2 years. All patients included in this study were Ph-positive. In two of them constitutional chromosomal aberrations were ascertained. In two patients the standard Ph translocation was accompanied within onset of BP by a clone with complex translocation and in three patients Ph chromosome was found in mosaics with normal karyotype. Standard translocation t(9.22) (q34;q11) as the sole chromosomal abnormality was found in 17 (31%) patients in BP and in 47 (69%) of patients in CP. The most frequent additional abnormalities found were +8, i(17q), +Ph and their combination, and other nonrandom chromosomal changes. Clonal evolution was proved in 11 out of 24 serially examined patients during the progression of the disease. The analysis of relationship between prognosis of the disease and the results of cytogenetic examination revealed significant differences, and a more favorable course of the disease was observed for the group of patients in CP and with Ph chromosome as the sole chromosomal aberration.
对122例慢性髓性白血病（CML）患者进行了细胞遗传学检查。在首次细胞遗传学检查时，其中68例处于疾病的慢性期（CP），54例处于急变期（BP）。整个组的平均年龄为44.8±15.2岁。本研究纳入的所有患者均为Ph阳性。其中2例确定存在先天性染色体畸变。2例患者在BP期发病时，标准的Ph易位伴有一个复杂易位的克隆，3例患者在正常核型的嵌合体中发现了Ph染色体。在BP期，17例（31%）患者和CP期47例（69%）患者中发现标准易位t(9;22)(q34;q11)是唯一的染色体异常。最常见的其他异常是+8、i(17q)、+Ph及其组合，以及其他非随机染色体变化。在24例连续检查的患者中，有11例在疾病进展过程中出现了克隆演变。对疾病预后与细胞遗传学检查结果之间关系的分析显示存在显著差异，CP期且以Ph染色体作为唯一染色体畸变的患者组疾病进程更有利。
