Fellay G, Gabriel J P
Clinique médicale de l'Hôpital Cantonal, Unité d'Hémodialyse, Fribourg.
Nephrologie. 1988;9(5):233-6.
The importance of mathematical modeling in dialysis arose recently as a consequence of the achievement of individualized treatment therapies. Two distinct models were used in our center, namely the urea kinetic model (UK) and the direct dialysis quantification (ddq), for the estimation of the urea distribution volume (V) and the urea generation rate (G). It turned out that, for the same patient, they provided us with different results. The basic hypotheses on which the two models rely are poorly described in the literature. The aim of this paper is an attempt to fill this gap and to show that the discrepancy observed between the two models is not surprising at all. The study also shows that from a theoretical viewpoint, ddq is more appropriate than UK for the estimation of V and G. The question of the intrinsic quality of ddq is not discussed here.
随着个体化治疗方法的实现，数学建模在透析中的重要性最近才凸显出来。我们中心使用了两种不同的模型，即尿素动力学模型（UK）和直接透析量化（ddq），来估计尿素分布容积（V）和尿素生成率（G）。结果发现，对于同一患者，这两种模型给出的结果不同。文献中对这两种模型所依赖的基本假设描述甚少。本文旨在填补这一空白，并表明两种模型之间观察到的差异一点也不令人惊讶。该研究还表明，从理论角度来看，在估计V和G方面，ddq比UK更合适。本文不讨论ddq的内在质量问题。
