Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
IRCCS SDN Naples, Via Emanuele Gianturco 113, 80143, Naples, Italy.
Cell Calcium. 2020 May;87:102194. doi: 10.1016/j.ceca.2020.102194. Epub 2020 Mar 7.
Sodium-calcium exchanger (NCX) 1 and 3, have been demonstrated to play a relevant role in controlling the intracellular homeostasis of sodium and calcium ions in physiological and patho-physiological conditions. While NCX1 and NCX3 knocking-down have been both implicated in brain ischemia, several aspects of the epigenetic regulation of these two antiporters transcription were not yet well characterized. In response to stroke, NCX1 and NCX3 transcriptional regulation occurs from specific promoter sequences. Several evidences have shown that the expression of NCX1 and NCX3 can be determined by epigenetic modifications, consisting in changes of the histone acetylation levels on their promoter sequences. An interesting issue is that histone modifications at the NCX1 and NCX3 promoters could be linked to neurodegeneration occurring after stroke. Therefore, identifying the epigenetic regulation at the NCX1 and NCX3 promoters could permit to identify new molecular targets that can open new strategies for stroke treatment. The current review reassumes the recent knowledge of histone modifications of NCX1 and NCX3 genes in brain in physiological and patho-physiological conditions.
钠钙交换蛋白（NCX）1 和 3 已被证明在生理和病理生理条件下在控制细胞内钠离子和钙离子的动态平衡方面发挥重要作用。虽然 NCX1 和 NCX3 的敲低都与脑缺血有关，但这两种转运蛋白转录的表观遗传调控的几个方面尚未得到很好的描述。在中风的反应中，NCX1 和 NCX3 的转录调控发生在特定的启动子序列上。有几项证据表明，NCX1 和 NCX3 的表达可以通过表观遗传修饰来决定，包括其启动子序列上组蛋白乙酰化水平的变化。一个有趣的问题是，NCX1 和 NCX3 启动子上的组蛋白修饰可能与中风后发生的神经退行性变有关。因此，确定 NCX1 和 NCX3 启动子的表观遗传调控可以确定新的分子靶点，为中风治疗开辟新的策略。本综述总结了 NCX1 和 NCX3 基因在生理和病理生理条件下在大脑中的组蛋白修饰的最新知识。
