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降主动脉病变的血管内治疗:Regis-TEVAR研究结果

Endovascular Treatment of Descending Thoracic Aortic Pathology: Results of the Regis-TEVAR Study.

作者信息

López Espada Cristina, Linares Palomino Jose Patricio, Domínguez González Jose Manuel, Iborra Ortega Elena, Lozano Vilardell Pascual, Solanich Valldaura Teresa, Volo Pérez Guido, Blanco Cañibano Estrella, Álvarez Salgado Andrés, Fernández Fernández Juan Carlos, Hernando Rydings Manuel, Miralles Hernández Manuel

机构信息

Vascular Surgery Unit, University Hospital Virgen de las Nieves of Granada, Spain.

Vascular Surgery Unit, University Hospital Virgen de las Nieves of Granada, Spain.

出版信息

Ann Vasc Surg. 2020 Aug;67:306-315. doi: 10.1016/j.avsg.2020.02.012. Epub 2020 Mar 13.

Abstract

BACKGROUND

Endovascular techniques have become an essential tool for treatment of thoracic aortic pathology. The objective of this study was to analyze indications and results of thoracic endovascular aortic repair (TEVAR) in vascular surgery units, through a retrospective and multicentric national registry called Regis-TEVAR.

METHODS

From 2012 to 2016, a total of 287 patients from 11 vascular surgery units, treated urgently and electively, were recruited consecutively. The primary variables analyzed are mortality, survival, and reintervention rate. The following indications for TEVAR were also analyzed: aortic dissections, thoracic aneurysms, traumatisms, and intramural hematomas or penetrating ulcers, as well as results and postoperative complications in accordance with each indication.

RESULTS

Of the 287 TEVAR performed (239 men, mean age 64.1 ± 14.1 years), 155 were because of aortic aneurysm (54%), 90 because of type B aortic dissection (31.4%), 36 because of traumatic aortic rupture (12.5%), and 6 because of penetrating ulcers or intramural hematomas (2.1%). Overall mortality at 30 days was 11.5% (18.5% in urgent and 5.3% in elective), being higher in dissections (13.3%). The median actuarial survival was 73% at 4 years. The stroke rate was 3.1%, and the rate of spinal cord ischemia was 4.9%. Aortic reoperations were necessary in 23 patients (8.1%).

CONCLUSIONS

This registry provides complete and reliable information on real clinical practice of TEVAR in Spain, with results similar to international series of open surgery. In accordance with these data, TEVAR can be performed with acceptable morbidity and mortality and with low rates of postoperative complications.

摘要

背景

血管内技术已成为治疗胸主动脉疾病的重要工具。本研究的目的是通过一项名为Regis - TEVAR的回顾性全国多中心登记研究,分析血管外科单位中胸主动脉腔内修复术(TEVAR)的适应证和结果。

方法

2012年至2016年,连续招募了来自11个血管外科单位的287例患者,包括急诊和择期治疗的患者。分析的主要变量为死亡率、生存率和再次干预率。还分析了TEVAR的以下适应证:主动脉夹层、胸主动脉瘤、创伤、壁内血肿或穿透性溃疡,以及每种适应证的结果和术后并发症。

结果

共进行了287例TEVAR手术(239例男性,平均年龄64.1±14.1岁),其中155例(54%)是因为主动脉瘤,90例(31.4%)是因为B型主动脉夹层,36例(12.5%)是因为创伤性主动脉破裂,6例(2.1%)是因为穿透性溃疡或壁内血肿。30天总体死亡率为11.5%(急诊为18.5%,择期为5.3%),夹层患者死亡率更高(13.3%)。4年时的中位精算生存率为73%。卒中发生率为3.1%,脊髓缺血发生率为4.9%。23例患者(8.1%)需要进行主动脉再次手术。

结论

该登记研究提供了关于西班牙TEVAR实际临床实践的完整且可靠的信息,结果与国际开放手术系列相似。根据这些数据,TEVAR可以在可接受的发病率和死亡率以及低术后并发症发生率的情况下进行。

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