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每日使用替诺福韦/恩曲他滨进行暴露前预防失败和延迟 HIV 血清转化的情况。

Failure of pre-exposure prophylaxis with daily tenofovir/emtricitabine and the scenario of delayed HIV seroconversion.

机构信息

Stanley Ho Centre for Emerging Infectious Diseases, Chinese University of Hong Kong, Shatin, Hong Kong.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.

出版信息

Int J Infect Dis. 2020 May;94:41-43. doi: 10.1016/j.ijid.2020.03.014. Epub 2020 Mar 13.

DOI:10.1016/j.ijid.2020.03.014
PMID:32173577
Abstract

Failure of pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine may occur despite perfect adherence, although this is uncommon. Failure results in breakthrough HIV infection. Delayed seroconversion associated with antiretroviral use may complicate the picture, causing uncertainties in interpreting adherence patterns for establishing the true cause of PrEP failure.

摘要

尽管患者完美遵从医嘱，仍可能出现替诺福韦酯和恩曲他滨的暴露前预防（PrEP）失败，尽管这种情况较为少见。PrEP 失败会导致突破性 HIV 感染。与抗逆转录病毒药物使用相关的血清转换延迟可能会使情况变得复杂，导致在解释确定 PrEP 失败的真正原因时对遵从医嘱模式的不确定性。

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