认知储备对轻度认知障碍患者临床和神经心理学测量的影响。
Impact of cognitive reserve on clinical and neuropsychological measures in patients with mild cognitive impairment.
机构信息
Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
DZNE, German Center for Neurodegenerative Diseases, Germany.
出版信息
Australas Psychiatry. 2020 Aug;28(4):386-390. doi: 10.1177/1039856220908171. Epub 2020 Mar 15.
OBJECTIVE
Cognitive reserve influences age of onset, speed of progression, and clinical manifestations of Alzheimer's disease. We investigated whether cognitive reserve interacts with clinical and neuropsychological parameters in mild cognitive impairment (MCI).
METHODS
In this cross-sectional study, we recruited 273 people (70.6 ± 10.1 years, 54.6% women) suffering from subjective memory complaints ( = 65), MCI ( = 121), or dementia ( = 87). Patients underwent neuropsychological evaluation, laboratory testing, and brain imaging. Additionally, we obtained information on years of education and help-seeking motivation.
RESULTS
MCI patients with a university degree were significantly older than those without (71.6 ± 9.6 vs. 66.9 ± 10.3, = 0.02). University-educated MCI patients demonstrated superior performance in verbal fluency. Intrinsic help-seeking motivation (self-referral) was associated with higher cognitive reserve. Female MCI patients presented with greater intrinsic motivation.
CONCLUSION
Cognitive reserve modulates clinical and neuropsychological measures in patients with MCI.
目的
认知储备影响阿尔茨海默病的发病年龄、进展速度和临床表现。我们研究了认知储备是否与轻度认知障碍（MCI）的临床和神经心理学参数相互作用。
方法
在这项横断面研究中，我们招募了 273 名患有主观记忆抱怨（n=65）、MCI（n=121）或痴呆（n=87）的人（年龄 70.6±10.1 岁，54.6%为女性）。患者接受了神经心理学评估、实验室测试和脑成像。此外，我们还获得了有关受教育年限和寻求帮助动机的信息。
结果
MCI 患者中具有大学学历的患者明显比没有大学学历的患者年龄更大（71.6±9.6 岁 vs. 66.9±10.3 岁， = 0.02）。具有大学学历的 MCI 患者在言语流畅性方面表现更好。内在的寻求帮助动机（自我推荐）与更高的认知储备有关。女性 MCI 患者表现出更高的内在动机。
结论
认知储备调节 MCI 患者的临床和神经心理学测量。
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