Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, P. R. China.
Department of Radiology, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, P. R. China.
World J Biol Psychiatry. 2020 Nov;21(9):685-695. doi: 10.1080/15622975.2020.1733082. Epub 2020 Mar 16.
Anxiety is a very common symptom and closely related to obsessive-compulsive symptoms in obsessive-compulsive disorder (OCD). However, the association between anxiety and obsessive-compulsive symptoms at the hippocampus network level remains unclear.
This study enrolled 42 patients with OCD and 42 healthy controls (HCs), who underwent resting-state functional magnetic resonance imaging (fMRI) and clinical evaluation. Multiple linear regression analysis was performed to investigate the behavioural significance and interactive effects of obsessive-compulsive and anxiety symptoms on the hippocampus functional connectivity (HFC). The mediation analysis model was used to explore whether the hippocampus functional connectivity (FC) network indirectly mediated the relationship between obsessive-compulsive symptoms and anxiety.
Results showed that the FCs with the cerebellum, middle temporal gyrus (MTG) and anterior cingulate gyrus (ACG) were increased in the hippocampus FC network in patients with OCD compared with those in HCs. The regions of interactive effects between anxiety and obsession, which are mainly located in the prefrontal cortex and MTG, were positively correlated. The mediation effect is 0.018 between obsession and anxiety on the HFC networks in patients with OCD.
The FC between the hippocampus and MTG plays a key role in the relationship between anxiety and obsession.
焦虑是强迫症（OCD）中非常常见的症状，且与强迫症状密切相关。然而，焦虑与海马网络中强迫症状之间的关联尚不清楚。
本研究纳入了 42 名强迫症患者和 42 名健康对照者（HCs），他们接受了静息态功能磁共振成像（fMRI）和临床评估。采用多元线性回归分析来研究强迫和焦虑症状对海马功能连接（HFC）的行为意义和交互作用。采用中介分析模型来探讨海马功能连接（FC）网络是否间接地介导了强迫症状与焦虑之间的关系。
结果显示，与 HCs 相比，强迫症患者的海马 FC 网络中与小脑、颞中回（MTG）和前扣带回（ACG）的 FC 增加。焦虑和强迫之间交互作用的区域主要位于前额叶皮层和 MTG，呈正相关。强迫症患者中，强迫和焦虑对 HFC 网络的中介效应为 0.018。
海马与 MTG 之间的 FC 在焦虑和强迫之间的关系中起关键作用。
