CIMA, Centre of Marine and Environmental Research, University of Algarve, Campus de Gambelas, 8000-139, Faro, Portugal.
CIMA, Centre of Marine and Environmental Research, University of Algarve, Campus de Gambelas, 8000-139, Faro, Portugal; Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.
Mar Environ Res. 2020 Apr;156:104904. doi: 10.1016/j.marenvres.2020.104904. Epub 2020 Feb 7.
This study assesses the sex-specific effects induced by CdTe QDs, on the marine mussel Mytilus galloprovincialis in comparison to its dissolved counterpart. A 14 days exposure to CdTe QDs and dissolved Cd was conducted (10 μg Cd L), analysing Cd accumulation, oxidative stress, biotransformation, metallothionein and oxidative damage in the gonads. Both Cd forms caused significant antioxidant alterations, whereby QDs were more pro-oxidant, leading to oxidative damage, being females more affected. Overall, biochemical impairments on gonads of M. galloprovincialis demonstrate that the reproductive toxicity induced by CdTe QDs in mussels are sex-dependent and mediated by oxidative stress and lipid peroxidation. It is crucial to acknowledge how gametes are affected by metal-based nanoparticles, such as Cd-based QDs. As well as understanding the potential changes they may undergo at the cellular level during gametogenesis, embryogenesis and larval development potentially leading to serious impacts on population sustainability and ecosystem health.
本研究评估了 CdTe QDs 对海洋贻贝（Mytilus galloprovincialis）的性别特异性影响，并将其与溶解态 Cd 进行了比较。通过 14 天的 CdTe QDs 和溶解态 Cd 暴露（10μg Cd L）实验，分析了 Cd 的积累、氧化应激、生物转化、金属硫蛋白和性腺氧化损伤。两种 Cd 形式均导致了显著的抗氧化改变，其中 QDs 更具促氧化作用，导致氧化损伤，雌性贻贝受影响更严重。总之，贻贝性腺的生化损伤表明，CdTe QDs 对贻贝的生殖毒性具有性别依赖性，并通过氧化应激和脂质过氧化介导。必须认识到金属基纳米颗粒（如 Cd 基 QDs）如何影响配子。了解它们在配子发生、胚胎发生和幼虫发育过程中在细胞水平上可能发生的潜在变化，可能会对种群可持续性和生态系统健康产生严重影响。
