Johnston A L, File S E
Department of Pharmacology, School of Pharmacy, University of London, U.K.
Psychiatry Res. 1988 Jul;25(1):81-90. doi: 10.1016/0165-1781(88)90161-8.
Two animal tests of anxiety (the elevated plus-maze and the social interaction test) were used to investigate the effects of several antipanic agents. In the elevated plus-maze, the triazolobenzodiazepines adinazolam (2 and 5 mg/kg) and alprazolam (1 mg/kg), tested after 5 days of pretreatment, demonstrated significant anxiolytic effects, while phenelzine (9 mg/kg), after 21 days of pretreatment, demonstrated nonsignificant anxiolytic effects. In the social interaction test, the triazolobenzodiazepines generally did not produce an anxiolytic profile, and phenelzine even revealed significant anxiogenic activity. The antipanic agents therefore distinguish between the two tests of anxiety. The lack of a strong anxiolytic profile with these agents in both tests lends support to the distinction between generalized anxiety and panic disorder.
采用两项焦虑动物试验（高架十字迷宫试验和社交互动试验）来研究几种抗惊恐药物的效果。在高架十字迷宫试验中，经过5天预处理后测试的三唑并苯二氮䓬类药物阿地唑仑（2和5毫克/千克）和阿普唑仑（1毫克/千克）显示出显著的抗焦虑作用，而经过21天预处理后的苯乙肼（9毫克/千克）显示出不显著的抗焦虑作用。在社交互动试验中，三唑并苯二氮䓬类药物一般未表现出抗焦虑特征，而苯乙肼甚至显示出显著的致焦虑活性。因此，抗惊恐药物在这两项焦虑试验中表现出差异。这些药物在两项试验中均缺乏强烈的抗焦虑特征，这支持了广泛性焦虑和惊恐障碍之间的区别。
