Eimery Saragol, Tangestani Hadith, Mansouri Sara, Kordvarkaneh Hamed, Rahimi-Foroushani Abbas, Shab-Bidar Sakineh
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.
J Res Med Sci. 2020 Feb 20;25:19. doi: 10.4103/jrms.JRMS_812_18. eCollection 2020.
Accumulating evidence suggests that diet is associated with kidney function. This study was carried out to examine the association between a posteriori dietary patterns and kidney function in older adults.
In a cross-sectional study, 266 older adults, aged 60-83 years, were included. Anthropometric measures were recorded. Biochemical measurements of blood and urine samples were measured. Information on diet was collected using a validated semi-quantified food frequency questionnaire with 168 food items and factor analysis performed to derive major dietary patterns. Estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease (CKD) Epidemiology Collaboration equation.
A total of 266 participants with mean body mass index (BMI) 29.75 ± 4.53 kg/m and age, 66.2 ± 5.3 years, were included in the current study. Three major dietary patterns were identified using factor analysis based on intake data (28% of the total variance of food intake in the population). After adjustment for age, sex, BMI, and energy intake, we found a positive significant relationship between the first pattern and eGFR ( = 0.031). A positive significant association between adherence to the traditional dietary pattern and urine creatinine was also observed ( = 0.035). In addition, in logistic regression model and after control for covariates, a positive association was observed between adherence to traditional dietary pattern with odds of eGFR < 60 ml/min/1.73 m ( = 0.043) and urinary albumin-to-creatinine ratio ≥ 30 mg/g ( = 0.038).
It is concluded that higher adherence to the healthy dietary pattern may improve renal function while Iranian traditional pattern was associated with significantly increased odds of incident CKD and albuminuria.
越来越多的证据表明饮食与肾功能有关。本研究旨在探讨老年人事后饮食模式与肾功能之间的关联。
在一项横断面研究中，纳入了266名年龄在60 - 83岁的老年人。记录了人体测量指标。对血液和尿液样本进行了生化检测。使用经过验证的半定量食物频率问卷收集饮食信息，该问卷包含168种食物，并进行因子分析以得出主要饮食模式。使用慢性肾脏病（CKD）流行病学协作方程计算估计肾小球滤过率（eGFR）。
本研究共纳入266名参与者，平均体重指数（BMI）为29.75±4.53kg/m²，年龄为66.2±5.3岁。基于摄入数据通过因子分析确定了三种主要饮食模式（占人群食物摄入总方差的28%）。在调整年龄、性别、BMI和能量摄入后，我们发现第一种模式与eGFR之间存在显著正相关（P = 0.031）。还观察到坚持传统饮食模式与尿肌酐之间存在显著正相关（P = 0.035）。此外，在逻辑回归模型中并在控制协变量后，观察到坚持传统饮食模式与eGFR < 60 ml/min/1.73 m²的几率（P = 0.043）和尿白蛋白与肌酐比值≥30 mg/g（P = 0.038）之间存在正相关。
得出的结论是，更高程度地坚持健康饮食模式可能改善肾功能，而伊朗传统饮食模式与慢性肾脏病和蛋白尿发生几率的显著增加有关。
