Öztürk Selen, Öztürk İbrahim
Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
Department of Anesthesiology and Reanimation, Göztepe Training and Research Hospital, Istanbul, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2020 Jan 23;28(1):101-107. doi: 10.5606/tgkdc.dergisi.2020.18387. eCollection 2020 Jan.
In this meta-analysis, we aimed to investigate the possible relationship between atrial fibrillation development after cardiac surgery and preoperative vitamin D levels.
Literature review was carried out in the PubMed, ScienceDirect and Ovid electronic databases without any limitation of time frame. Published studies which recorded the preoperative levels of vitamin D and atrial fibrillation after cardiac surgery in the English language were included. The results of the studies were evaluated based on either random or fixed effect model according to the presence of heterogeneity (I>25%).
A total of 1,865 articles were screened. After the article titles and abstracts were analyzed, six articles involving 769 patients which met the inclusion criteria were included. The results indicated that there was a relationship between preoperative vitamin D levels and postoperative atrial fibrillation (SMD: -0.46, 95% CI: -0.79 to -0.12; p<0.007). Heterogeneity was observed for studies conducted (I =76.1%).
We concluded that low preoperative vitamin D levels were associated with the development of atrial fibrillation after cardiac surgery. However, there is a need for large-scale, randomized-controlled trials for preventing the heterogeneity of the results.
在这项荟萃分析中，我们旨在研究心脏手术后房颤发生与术前维生素D水平之间的可能关系。
在PubMed、ScienceDirect和Ovid电子数据库中进行文献综述，不受时间框架限制。纳入以英文发表的记录心脏手术后维生素D术前水平和房颤情况的研究。根据异质性（I>25%）的存在，基于随机或固定效应模型评估研究结果。
共筛选出1865篇文章。在分析文章标题和摘要后，纳入了6篇涉及769例符合纳入标准患者的文章。结果表明，术前维生素D水平与术后房颤之间存在关联（标准化均数差：-0.46，95%置信区间：-0.79至-0.12；p<0.007）。所纳入研究存在异质性（I=76.1%）。
我们得出结论，术前维生素D水平低与心脏手术后房颤的发生有关。然而，需要进行大规模的随机对照试验以防止结果的异质性。
