• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients.阻断OX40/OX40L通路并联合乙烯碳二亚胺固定的供体脾细胞可诱导致敏受体产生供体特异性同种异体移植耐受。
Ann Transl Med. 2020 Feb;8(4):84. doi: 10.21037/atm.2019.12.146.
2
Regulatory T cells are critical to tolerance induction in presensitized mouse transplant recipients through targeting memory T cells.调节性 T 细胞通过靶向记忆 T 细胞对致敏小鼠移植受者的诱导耐受至关重要。
Am J Transplant. 2010 Aug;10(8):1760-73. doi: 10.1111/j.1600-6143.2010.03186.x. Epub 2010 Jul 15.
3
Ethylene carbodiimide-fixed donor splenocytes combined with α-1 antitrypsin induce indefinite donor-specific protection to mice cardiac allografts.乙烯碳二亚胺固定的供体脾细胞与α-1抗胰蛋白酶联合使用可诱导对小鼠心脏同种异体移植的无限期供体特异性保护。
Transpl Int. 2017 Mar;30(3):305-317. doi: 10.1111/tri.12903.
4
Ethylene carbodiimide-fixed donor splenocytes combined with cordycepin induce long-term protection to mice cardiac allografts.乙烯亚胺固定供者脾细胞联合虫草素诱导小鼠心脏移植物的长期保护。
Transpl Immunol. 2019 Oct;56:101196. doi: 10.1016/j.trim.2019.02.001. Epub 2019 Feb 8.
5
Transfusion of ethylene carbodiimide-fixed donor splenocytes prolongs survival of vascularized skin allografts.乙二胺碳二亚胺固定的供体脾细胞输血可延长血管化皮肤同种异体移植物的存活时间。
J Surg Res. 2018 Jan;221:343-352. doi: 10.1016/j.jss.2017.06.005. Epub 2017 Oct 19.
6
Anti-OX40L monoclonal antibody prolongs secondary heart allograft survival based on CD40/CD40L and LFA-1/ICAM-1 blockade.抗OX40L单克隆抗体基于CD40/CD40L和LFA-1/ICAM-1阻断作用延长心脏同种异体移植的二次存活时间。
Transpl Immunol. 2015 Mar;32(2):84-91. doi: 10.1016/j.trim.2015.01.001. Epub 2015 Jan 19.
7
ECDI-fixed allogeneic splenocytes combined with α1-antitrypsin prolong survival of rat renal allografts.ECDI 固定的同种异体脾细胞与α1-抗胰蛋白酶联合使用可延长大鼠肾移植的存活时间。
Int Immunopharmacol. 2015 May;26(1):43-9. doi: 10.1016/j.intimp.2015.02.035. Epub 2015 Mar 5.
8
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.乙烯碳二亚胺固定供者脾细胞输注可特异性地针对同种异体识别的直接和间接途径，诱导移植耐受。
J Immunol. 2012 Jul 15;189(2):804-12. doi: 10.4049/jimmunol.1103705. Epub 2012 Jun 13.
9
Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions.移植脾细胞输注固定的 ECDI 诱导心脏移植物耐受：通过树突细胞内浸润的 CD11b（+）IDO（+）细胞实现
Am J Transplant. 2012 Nov;12(11):2920-9. doi: 10.1111/j.1600-6143.2012.04203.x. Epub 2012 Aug 6.
10
Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.短暂性 B 细胞耗竭联合凋亡供者脾细胞诱导胰岛异种移植物的异种特异性 T 和 B 细胞耐受。
Diabetes. 2013 Sep;62(9):3143-50. doi: 10.2337/db12-1678. Epub 2013 Jul 12.

引用本文的文献

1
Tolerogenic Therapies in Cardiac Transplantation.心脏移植中的耐受性疗法
Int J Mol Sci. 2025 Apr 23;26(9):3968. doi: 10.3390/ijms26093968.
2
Negative Vaccination Strategies for Promotion of Transplant Tolerance.消极免疫策略促进移植耐受。
Transplantation. 2024 Aug 1;108(8):1715-1729. doi: 10.1097/TP.0000000000004911. Epub 2024 Feb 16.
3
The Entangled World of Memory T Cells and Implications in Transplantation.记忆性T细胞的复杂世界及其在移植中的意义
Transplantation. 2024 Jan 1;108(1):137-147. doi: 10.1097/TP.0000000000004647. Epub 2023 Dec 13.

本文引用的文献

1
Lactate dehydrogenase as a prognostic marker of renal transplant recipients with severe community-acquired pneumonia: a 10-year retrospective study.乳酸脱氢酶作为重症社区获得性肺炎肾移植受者的预后标志物：一项10年回顾性研究
Ann Transl Med. 2019 Nov;7(22):660. doi: 10.21037/atm.2019.10.75.
2
OGTT 2-hour serum C-peptide index as a predictor of post-transplant diabetes mellitus in kidney transplant recipients.口服葡萄糖耐量试验2小时血清C肽指数作为肾移植受者移植后糖尿病的预测指标。
Ann Transl Med. 2019 Oct;7(20):538. doi: 10.21037/atm.2019.10.14.
3
Ethylene carbodiimide-fixed donor splenocytes combined with cordycepin induce long-term protection to mice cardiac allografts.乙烯亚胺固定供者脾细胞联合虫草素诱导小鼠心脏移植物的长期保护。
Transpl Immunol. 2019 Oct;56:101196. doi: 10.1016/j.trim.2019.02.001. Epub 2019 Feb 8.
4
Transfusion of ethylene carbodiimide-fixed donor splenocytes prolongs survival of vascularized skin allografts.乙二胺碳二亚胺固定的供体脾细胞输血可延长血管化皮肤同种异体移植物的存活时间。
J Surg Res. 2018 Jan;221:343-352. doi: 10.1016/j.jss.2017.06.005. Epub 2017 Oct 19.
5
Ethylene carbodiimide-fixed donor splenocytes combined with α-1 antitrypsin induce indefinite donor-specific protection to mice cardiac allografts.乙烯碳二亚胺固定的供体脾细胞与α-1抗胰蛋白酶联合使用可诱导对小鼠心脏同种异体移植的无限期供体特异性保护。
Transpl Int. 2017 Mar;30(3):305-317. doi: 10.1111/tri.12903.
6
Anti-OX40L monoclonal antibody prolongs secondary heart allograft survival based on CD40/CD40L and LFA-1/ICAM-1 blockade.抗OX40L单克隆抗体基于CD40/CD40L和LFA-1/ICAM-1阻断作用延长心脏同种异体移植的二次存活时间。
Transpl Immunol. 2015 Mar;32(2):84-91. doi: 10.1016/j.trim.2015.01.001. Epub 2015 Jan 19.
7
Memory T Cells in Transplantation.移植中的记忆性T细胞。
Curr Transplant Rep. 2014 Sep 1;1(3):137-146. doi: 10.1007/s40472-014-0018-5.
8
Inhibition of the interleukin-6 signaling pathway: a strategy to induce immune tolerance.抑制白细胞介素-6 信号通路：诱导免疫耐受的一种策略。
Clin Rev Allergy Immunol. 2014 Oct;47(2):163-73. doi: 10.1007/s12016-014-8413-3.
9
Memory T Cells Mediate Cardiac Allograft Vasculopathy and are Inactivated by Anti-OX40L Monoclonal Antibody.记忆 T 细胞介导心脏同种异体移植物血管病，并被抗 OX40L 单克隆抗体失活。
Cardiovasc Drugs Ther. 2014 Apr;28(2):115-22. doi: 10.1007/s10557-013-6502-9.
10
Memory T cells in transplantation - progress and challenges.移植中的记忆 T 细胞——进展与挑战。
Curr Opin Organ Transplant. 2013 Aug;18(4):387-92. doi: 10.1097/MOT.0b013e3283626130.

阻断OX40/OX40L通路并联合乙烯碳二亚胺固定的供体脾细胞可诱导致敏受体产生供体特异性同种异体移植耐受。

Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients.

作者信息

Lai Xingqiang, Yao Zhongpeng, Ning Fen, Zhang Lei, Fang Jiali, Li Guanghui, Xu Lu, Xiong Yunyi, Liu Luhao, Chen Rongxin, Ma Junjie, Chen Zheng

机构信息

Organ Transplant Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.

Guangzhou Institute of Pediatrics, Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.

出版信息

Ann Transl Med. 2020 Feb;8(4):84. doi: 10.21037/atm.2019.12.146.

DOI:10.21037/atm.2019.12.146
PMID:32175377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7048988/
Abstract

BACKGROUND

Memory T cells (Tms) are the major barrier preventing long-term allograft survival in presensitized transplant recipients. The OX40/OX40L pathway is important in the induction and maintenance of Tms.

METHODS

In this study, we added anti-OX40L mAb to ethylene-carbodiimide-fixed donor splenocytes (ECDI-SPs)-a method which is effective in inducing allograft tolerance in non-presensitized mouse heart transplant model. Recipient mice received heart transplantation after 6 weeks of donor skin presensitization and were treated with anti-OX40L mAb, ECDI-SPs or anti-OX40L mAb + ECDI-SPs, respectively.

RESULTS

Our data showed that the combination of ECDI-SPs and anti-OX40L mAb induced donor-specific tolerance in skin-presensitized heart transplant recipients, with the mechanism for this being associated with suppression of Tms and upregulation of CD4CD25Foxp3 T regulatory cells (Tregs). Importantly, CD25 T-cell depletion in the combined therapy-treated recipients broke the establishment of allograft tolerance, whereas adoptive transfer of presensitization-derived T cells into tolerant recipients suppressed Tregs expansion and abolished established tolerance.

CONCLUSIONS

Blockade of OX40/OX40L pathway in combination with ECDI-SPs appears to modulate the Tms/Tregs imbalance so as to create a protective milieu and induce graft tolerance in presensitized recipients.

摘要

背景

记忆性T细胞（Tm）是致敏移植受者中长期同种异体移植存活的主要障碍。OX40/OX40L通路在Tm的诱导和维持中起重要作用。

方法

在本研究中，我们将抗OX40L单克隆抗体添加到乙烯-碳二亚胺固定的供体脾细胞（ECDI-SP）中——该方法在非致敏小鼠心脏移植模型中诱导同种异体移植耐受有效。受体小鼠在供体皮肤致敏6周后接受心脏移植，并分别用抗OX40L单克隆抗体、ECDI-SP或抗OX40L单克隆抗体+ECDI-SP进行治疗。

结果

我们的数据表明，ECDI-SP与抗OX40L单克隆抗体联合使用可在皮肤致敏的心脏移植受者中诱导供体特异性耐受，其机制与Tm的抑制和CD4CD25Foxp3调节性T细胞（Treg）的上调有关。重要的是，联合治疗组受者的CD25 T细胞耗竭破坏了同种异体移植耐受的建立，而将致敏来源的T细胞过继转移到耐受受者中可抑制Treg的扩增并消除已建立的耐受。

结论

阻断OX40/OX40L通路并联合ECDI-SP似乎可调节Tm/Treg失衡，从而创造一个保护性环境并在致敏受者中诱导移植耐受。