Xi Zheng, Wu Yunfeng, Xiang Shouyang, Sun Chu, Wang Yongxuan, Yu Haiming, Fu Yu, Wang Xintao, Yan Jinglong, Zhao Dewei, Wang Yaming, Zhang Nan
The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang, People's Republic of China.
Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150001, Heilongjiang, People's Republic of China.
ACS Omega. 2020 Feb 25;5(9):4548-4557. doi: 10.1021/acsomega.9b03889. eCollection 2020 Mar 10.
A hydrothermal (HT) coating was applied to the biomedical Mg-Zn-Ca alloy surface by microarc oxidation (MAO) and heat treatment. Then, the corrosion resistance and biocompatibility of the coated alloy was evaluated in vitro and in vivo. The corrosion rate (CR) of HT-coated implants was significantly lower in experiment. In addition, this CR increased over time in vivo but was stable, albeit higher, in vitro. The proliferation, adhesion, and live activity of bone marrow stem cells (BMSCs) were significantly greater on the surface of the HT-coated Mg alloy in vitro. Serum Mg was always within the normal range in rabbits with implants, although Ca was higher than normal for both uncoated and coated scaffolds. There were no significant pathological effects on the main organs of alloy-implanted rabbits compared with healthy animals. Thus, the HT coating significantly improved the corrosion resistance and biocompatibility of the Mg-Zn-Ca alloy.
通过微弧氧化（MAO）和热处理在生物医学Mg-Zn-Ca合金表面施加了水热（HT）涂层。然后，在体外和体内评估了涂层合金的耐腐蚀性和生物相容性。实验中，HT涂层植入物的腐蚀速率（CR）显著更低。此外，该CR在体内随时间增加，但在体外虽更高却保持稳定。体外时，骨髓干细胞（BMSC）在HT涂层Mg合金表面的增殖、黏附及活性显著更强。植入支架的兔子血清镁始终在正常范围内，不过未涂层和涂层支架的钙均高于正常水平。与健康动物相比，合金植入兔子的主要器官未出现明显病理影响。因此，HT涂层显著改善了Mg-Zn-Ca合金的耐腐蚀性和生物相容性。
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