Wang Yuan, Kong Liangliang, Sun Buhao, Cui Jie, Shen Weimin
Department of Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
J Craniofac Surg. 2020 Jun;31(4):1074-1077. doi: 10.1097/SCS.0000000000006301.
Kaposiform hemangioendothelioma is an aggressive vascular tumor with infiltrative growth that commonly occurs in infancy and is associated with a life-threatening consumptive coagulopathy, as well as Kasabach-Merritt phenomenon. Recently, promising results have shown that sirolimus had been successfully used to treat Kasabach-Merritt phenomenon without significant toxicity. However, the situation the authors encountered in treating infants was not so satisfactory. Here, the authors present 2 patients younger than 3 months with refractory Kaposiform hemangioendothelioma treated with sirolimus and experienced severe pneumonia. The outcomes suggest that it is necessary to keep an eye on any symptoms indicate the infection of respiratory tract and use the antibiotics in time. The 2 cases also remind us of the potential sign that indicate the recurrence of KMP, which refers to firmer lesion with deepen color, especially when it comes with complications.
卡波西型血管内皮瘤是一种具有浸润性生长的侵袭性血管肿瘤，常见于婴儿期，与危及生命的消耗性凝血病以及卡萨巴赫-梅里特现象相关。最近，有前景的结果表明西罗莫司已成功用于治疗卡萨巴赫-梅里特现象且无明显毒性。然而，作者在治疗婴儿时遇到的情况并不那么令人满意。在此，作者介绍2例3个月以下难治性卡波西型血管内皮瘤患儿，接受西罗莫司治疗后出现严重肺炎。结果表明，有必要留意任何提示呼吸道感染的症状并及时使用抗生素。这2例病例也提醒我们注意卡萨巴赫-梅里特现象复发的潜在迹象，即病变变硬且颜色加深，尤其是伴有并发症时。
