Department of Radiology, Anhui Provincial Children's Hospital, Hefei, China.
Ann Med. 2023 Dec;55(1):2196090. doi: 10.1080/07853890.2023.2196090.
This retrospective study aimed to observe the efficacy of transcatheter arterial chemoembolization (TACE) combined with sirolimus in the treatment of haemangioma combined with the Kasabach-Merritt phenomenon (KMP).
A total of 11 infants with KMP who were treated at our hospital from January 2016 to September 2021 were selected and treated with arteriosclerosis embolotherapy using a microsphere emulsion formed by bleomycin + ultra-fluid lipiodol + dexamethasone + contrast agent or bleomycin mixed microspheres as the embolising agent. The patients were administered sirolimus orally after TACE. The clinical efficacy and examination indicators before and after treatment were observed and compared.
The 11 infants underwent TACE treatment by arteriosclerosis embolotherapy a total of 21 times; of these cases, 10 were cured, and 1 showed a moderate response. There were no cases of non-response or death. The platelet count rose from 10.0 (7.0, 18.0) x 10/L before TACE to 236.0 (188.0, 275.0) x 10/L six months after the first TACE, and the tumour size decreased from 49.0 (43.0, 111.7) cm before TACE to 7.0 (3.5, 17.0) cm six months after the first TACE. The differences were statistically significant (the Z values were -2.943 and -2.934, respectively, < 0.05).
The combination of TACE and sirolimus has significant efficacy on critical children with KMP.
本回顾性研究旨在观察经导管动脉化疗栓塞（TACE）联合西罗莫司治疗伴有卡-梅现象（KMP）的血管瘤的疗效。
选取 2016 年 1 月至 2021 年 9 月我院收治的 11 例伴有 KMP 的婴儿患者，采用硬化栓塞疗法，以平阳霉素+超液化碘油+地塞米松+造影剂微球乳液或平阳霉素混合微球作为栓塞剂。TACE 后，患儿口服西罗莫司。观察并比较治疗前后的临床疗效和检查指标。
11 例患儿共行 TACE 治疗 21 次，其中硬化栓塞治疗 10 例痊愈，1 例显效，无无效或死亡病例。血小板计数由 TACE 前的 10.0（7.0，18.0）×10/L 升高至首次 TACE 后 6 个月的 236.0（188.0，275.0）×10/L，肿瘤大小由 TACE 前的 49.0（43.0，111.7）cm 缩小至首次 TACE 后 6 个月的 7.0（3.5，17.0）cm，差异均有统计学意义（Z 值分别为-2.943、-2.934，均<0.05）。
TACE 联合西罗莫司治疗伴有 KMP 的危重症儿童具有显著疗效。
