认知正常个体的区域性淀粉样蛋白积累与白质完整性。

Regional Amyloid Accumulation and White Matter Integrity in Cognitively Normal Individuals.

机构信息

Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, China.

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, China.

出版信息

J Alzheimers Dis. 2020;74(4):1261-1270. doi: 10.3233/JAD-191350.

DOI:10.3233/JAD-191350

PMID:32176644

Abstract

BACKGROUND

Recent studies have shown that amyloid-β (Aβ) burden influenced white matter (WM) integrity before the onset of dementia.

OBJECTIVE

To assess whether the effects of Aβ burden on WM integrity in cognitively normal (CN) individuals were regionally specific.

METHODS

Our cohort consisted of 71 CNs from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database who underwent both AV45 amyloid-PET and diffusion tensor imaging. Standardized uptake value ratio (SUVR) was computed across four bilateral regions of interest (ROIs) corresponding to four stages of in vivo amyloid staging model (Amyloid stages I-IV). Linear regression models were conducted in entire CN group and between APOEɛ4 carriers and non-carriers.

RESULTS

Our results indicated that higher global Aβ-SUVR was associated with higher mean diffusivity (MD) in the entire CN group (p = 0.023), and with both higher MD (p = 0.015) and lower fractional anisotropy (FA) (p = 0.026) in APOEɛ4 carriers. Subregion analysis showed that higher Amyloid stage I-II Aβ-SUVRs were associated with higher MD (Stage-1: p = 0.030; Stage-2: p = 0.016) in the entire CN group, and with both higher MD (Stage-1: p = 0.004; Stage-2: p = 0.010) and lower FA (Stage-1: p = 0.022; Stage-2: p = 0.014) in APOEɛ4 carriers. No associations were found in APOEɛ4 non-carriers and in Amyloid stage III-IV ROIs.

CONCLUSIONS

Our results indicated that the effects of Aβ burden on WM integrity in CNs might be regionally specific, particularly in Amyloid stage I-II ROIs, and modulated by APOEɛ4 status.

摘要

背景

最近的研究表明，淀粉样蛋白-β（Aβ）负担在痴呆症发病前会影响白质（WM）的完整性。

目的

评估在认知正常（CN）个体中，Aβ负担对 WM 完整性的影响是否具有区域性特异性。

方法

我们的队列由来自阿尔茨海默病神经影像学倡议（ADNI）数据库的 71 名 CN 组成，他们均接受了 AV45 淀粉样蛋白-PET 和弥散张量成像（DTI）检查。计算了与体内淀粉样蛋白分期模型（淀粉样蛋白分期 I-IV）的四个阶段相对应的四个双侧感兴趣区（ROI）的标准化摄取值比（SUVR）。在整个 CN 组以及 APOEɛ4 携带者和非携带者之间进行了线性回归模型分析。

结果

我们的结果表明，在整个 CN 组中，较高的全局 Aβ-SUVR 与较高的平均弥散度（MD）相关（p=0.023），在 APOEɛ4 携带者中，与较高的 MD（p=0.015）和较低的各向异性分数（FA）（p=0.026）相关。亚区分析显示，在整个 CN 组中，较高的淀粉样蛋白分期 I-II Aβ-SUVR 与较高的 MD（分期 1：p=0.030；分期 2：p=0.016）相关，在 APOEɛ4 携带者中，与较高的 MD（分期 1：p=0.004；分期 2：p=0.010）和较低的 FA（分期 1：p=0.022；分期 2：p=0.014）相关。在 APOEɛ4 非携带者和淀粉样蛋白分期 III-IV ROI 中未发现相关性。