在成年期，年龄依赖性淀粉样蛋白沉积与认知正常成年人的白质改变有关。
Age-dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span.
作者信息
Caballero Miguel Á Araque, Song Zhuang, Rubinski Anna, Duering Marco, Dichgans Martin, Park Denise C, Ewers Michael
机构信息
Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.
Center for Vital Longevity, University of Texas at Dallas, Dallas, Texas.
出版信息
Alzheimers Dement. 2020 Apr;16(4):651-661. doi: 10.1002/alz.12062. Epub 2020 Mar 8.
INTRODUCTION
Both beta-amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear.
METHODS
Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30-89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F-18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension.
RESULTS
Subjects with abnormal amyloid PET (n = 87) showed stronger age-related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter.
DISCUSSION
Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age-dependent manner in cognitively normal individuals.
引言
β-淀粉样蛋白（Aβ）沉积和白质完整性下降是在阿尔茨海默病（AD）中观察到的脑部改变，在第四个和第五个十年开始出现。然而，无症状受试者中这两种脑部改变之间的关联尚不清楚。
方法
对282名认知正常的受试者（年龄30 - 89岁）进行淀粉样蛋白正电子发射断层扫描（PET）和扩散张量成像（DTI）。我们评估了年龄与异常淀粉样蛋白PET状态（氟代贝他吡F - 18 PET > 1.2标准摄取值比率[SUVR]）对区域平均扩散率（MD）和全脑白质高信号（WMH）体积的相互作用，并对性别、教育程度和高血压进行了控制。
结果
淀粉样蛋白PET异常的受试者（n = 87）在全脑WMH和区域MD方面表现出更强的年龄相关增加，特别是在白质的顶叶后部区域。
讨论
在认知正常个体中，散发性Aβ沉积以年龄依赖的方式与AD好发区域的白质改变相关。
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