非侵入性小脑刺激在神经退行性共济失调中的应用：文献综述。
Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review.
机构信息
Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Arthur and Hinda Marcus Institute for Aging Brain, Hebrew SeniorLife and Department of Neurology, Harvard Medical School, Boston, MA 02131, USA.
出版信息
Int J Mol Sci. 2020 Mar 12;21(6):1948. doi: 10.3390/ijms21061948.
Abstract
Cerebellar ataxias are a heterogenous group of degenerative disorders for which we currently lack effective and disease-modifying interventions. The field of non-invasive brain stimulation has made much progress in the development of specific stimulation protocols to modulate cerebellar excitability and try to restore the physiological activity of the cerebellum in patients with ataxia. In light of limited evidence-based pharmacologic and non-pharmacologic treatment options for patients with ataxia, several different non-invasive brain stimulation protocols have emerged, particularly employing repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) techniques. In this review, we summarize the most relevant rTMS and tDCS therapeutic trials and discuss their implications in the care of patients with degenerative ataxias.
摘要
小脑共济失调是一组异质性退行性疾病，目前我们缺乏有效的、能改变疾病进程的干预措施。非侵入性脑刺激领域在开发特定的刺激方案以调节小脑兴奋性并试图恢复小脑共济失调患者的生理活动方面取得了很大进展。鉴于目前针对小脑共济失调患者的基于证据的药物和非药物治疗选择有限，已经出现了几种不同的非侵入性脑刺激方案，特别是采用重复经颅磁刺激（rTMS）或经颅直流电刺激（tDCS）技术。在这篇综述中，我们总结了最相关的 rTMS 和 tDCS 治疗试验，并讨论了它们在退行性小脑共济失调患者治疗中的意义。
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