Fang Clarissa Ern Hui, Crowe Catherine, Murphy Annette, O'Donnell Martin, Finucane Francis M
Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, Galway, Ireland.
HRB Clinical Research Facility, National University of Ireland Galway, Galway, H91 YR71, Ireland.
BMC Res Notes. 2020 Mar 16;13(1):156. doi: 10.1186/s13104-020-05006-4.
Skin tags are associated with an insulin resistant phenotype but studies in White Europeans with morbid obesity are lacking. We sought to determine whether the presence of cervical or axillary skin tags was associated with increased cardiovascular risk in Irish adults with morbid obesity. We conducted a cross-sectional study of patients attending our Irish regional bariatric centre with a BMI ≥ 40 kg m (or ≥ 35 kg m with co-morbidities). We compared anthropometric and metabolic characteristics in those with versus without skin tags.
Of 164 patients, 100 (31 male, 37 with type 2 diabetes, 36 on lipid lowering therapy, 41 on antihypertensive therapy) participated. Mean age was 53.7 ± 11.3 (range 31.1-80) years. Cervical or axillary tags were present in 85 patients. Those with tags had higher systolic blood pressure 138.0 ± 16.0 versus 125.1 ± 8.3 mmHg, p = 0.003) and HbA1c (46.5 ± 13.2 versus 36.8 ± 3.5 mmol/mol, p = 0.017). Tags were present in 94.6% of patients with diabetes, compared to 79.4% of those without diabetes (p = 0.039). Antihypertensive therapy was used by 45.8% of patients with skin tags compared to 13.3% without tags (p = 0.018). In bariatric clinic attenders skin tags were associated with higher SBP and HbA1c and a higher prevalence of diabetes and hypertension, consistent with increased vascular risk, but lipid profiles were similar.
皮赘与胰岛素抵抗表型相关，但缺乏对病态肥胖的欧洲白人的研究。我们试图确定在爱尔兰病态肥胖成年人中，颈部或腋窝皮赘的存在是否与心血管风险增加有关。我们对爱尔兰地区减肥中心BMI≥40 kg/m（或合并症时≥35 kg/m）的患者进行了一项横断面研究。我们比较了有皮赘和无皮赘患者的人体测量和代谢特征。
164例患者中，100例（31例男性，37例2型糖尿病患者，36例接受降脂治疗，41例接受抗高血压治疗）参与研究。平均年龄为53.7±11.3（范围31.1 - 80）岁。85例患者有颈部或腋窝皮赘。有皮赘的患者收缩压更高（138.0±16.0对125.1±8.3 mmHg，p = 0.003），糖化血红蛋白更高（46.5±13.2对36.8±3.mmol/mol，p = 0.017）。94.6%的糖尿病患者有皮赘，而无糖尿病患者中这一比例为79.4%（p = 0.039）。45.8%有皮赘的患者使用抗高血压治疗，无皮赘患者中这一比例为13.3%（p = 0.018）。在减肥门诊患者中，皮赘与更高的收缩压、糖化血红蛋白以及更高的糖尿病和高血压患病率相关，这与血管风险增加一致，但血脂谱相似。
