Oleĭnik V A, Matiashina G I
Ter Arkh. 1988;60(9):43-6.
Components of the kallikrein-kinin system of the blood and some hemostatic indices were studied in parallel in 32 patients with diffuse toxic goiter. A decrease in the levels of prekallikrein, kininogen, the activity of kallikrein and kininase inhibitors in the blood plasma of the examinees resulted in raised activity of the kallikrein-kinin system in decompensated thyrotoxicosis. Hemostatic changes were characterized by signs of chronic disseminated intravascular coagulation. It was shown that kinin formation and blood coagulation were correlated. A certain parallelism in the increment of the activity of the kinin system and disorders of hemocoagulation was noted with an increase in a degree of severity of thyrotoxicosis. A tendency to improved indices was also noted after thyrostatic therapy.
对32例弥漫性毒性甲状腺肿患者同时研究了血液中激肽释放酶-激肽系统的成分和一些止血指标。受检者血浆中前激肽释放酶、激肽原、激肽释放酶和激肽酶抑制剂活性水平降低，导致失代偿性甲状腺毒症时激肽释放酶-激肽系统活性升高。止血变化以慢性弥散性血管内凝血迹象为特征。结果表明，激肽形成与血液凝固相关。随着甲状腺毒症严重程度的增加，激肽系统活性增加与血液凝固紊乱之间存在一定的平行关系。甲状腺功能抑制治疗后也注意到指标有改善的趋势。
