Kovtunova M E, Voronchikhina L D, Riabova T I, Riabov N V
Ter Arkh. 1988;60(9):77-9.
The authors reported the results of retrospective analysis of the level of polyamines in urine and the duration of clinicohematological remission in 25 AL children aged 3 to 14. Of this number 23 patients suffered from acute lymphoblastic leukemia, 2--from acute myeloblastic leukemia. Direct correlation between polyamine changes during a course of chemotherapy and the duration of remission was established. Longer duration was observed in the patients in whom a 2-fold rise of the level of all polyamines, especially spermidine, followed the administration of a cytostatic within the first 24-72 h. On the discontinuation of therapy a certain decrease in polyamine excretion with urine was observed in these children as compared to the level determined on their admission to hospital.
作者报告了对25名3至14岁急性白血病（AL）儿童尿液中多胺水平及临床血液学缓解持续时间的回顾性分析结果。其中23例患者患有急性淋巴细胞白血病，2例患有急性髓细胞白血病。化疗过程中多胺变化与缓解持续时间之间建立了直接相关性。在最初24至72小时内给予细胞抑制剂后所有多胺水平，尤其是亚精胺水平升高两倍的患者中观察到缓解持续时间更长。与入院时测定的水平相比，这些儿童在治疗中断后尿中多胺排泄量有一定程度下降。
