School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom; Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Department of Neuroradiology, St. Michael's Hospital, Toronto, Ontario, Canada.
World Neurosurg. 2020 Jul;139:111-120. doi: 10.1016/j.wneu.2020.02.101. Epub 2020 Mar 13.
Surgical clipping of intracranial aneurysms is typically robust and durable. However, residual aneurysmal components may be seen after clipping. Furthermore, there may be occasional aneurysmal recurrence. These factors are both clinically relevant because subarachnoid hemorrhage after clipping is a rare but important event. The rationale for any treatment is to substantially decrease the future risk of hemorrhage. Small series have shown coiling as a retreatment strategy after unsuccessful clipping, but none has explored the feasibility of Woven Endobridge (WEB) implantation.
We examined the feasibility of WEB implantation as second-line treatment for wide-necked residual aneurysms after unsuccessful clipping. We also recorded the safety and efficacy in this small series of 6 patients. To determine safety, we measured the modified Rankin Scale score before and after the procedure, and at 2 later time points (mean follow-up, 5 months and 15 months). To determine efficacy, we obtained radiographic aneurysm occlusion outcomes (including WEB Occlusion Scale) at these 2 time points. Four middle cerebral artery and 2 anterior communicating artery complex aneurysms were treated with WEB implantation, showing feasibility in 6/6 cases (100%). Follow-up at 15 months showed no change from preprocedural modified Rankin Scale score and there were no other complications. There was adequate occlusion in 5/6 cases (83%).
WEB implantation provided a feasible option in this challenging retreatment scenario. This is a small series and prospective data are required to make outcome inferences for this population. Nonetheless, we observed no complications and high adequate occlusion rates.
颅内动脉瘤的手术夹闭通常是可靠且持久的。然而,夹闭后可能仍可见残余的动脉瘤部分。此外,偶尔也会出现动脉瘤复发。这些因素在临床上都很重要,因为夹闭后的蛛网膜下腔出血是一种罕见但很重要的事件。任何治疗的基本原理都是大大降低未来出血的风险。小系列研究表明,在夹闭不成功的情况下,线圈是一种再治疗策略,但没有研究过编织式支架(WEB)植入的可行性。
我们研究了 WEB 植入作为夹闭不成功后宽颈残余动脉瘤二线治疗的可行性。我们还记录了这 6 例患者的小系列的安全性和疗效。为了确定安全性,我们在术前、术后以及 2 个后续时间点(平均随访时间为 5 个月和 15 个月)测量改良 Rankin 量表评分。为了确定疗效,我们在这 2 个时间点获得了影像学动脉瘤闭塞结果(包括 WEB 闭塞量表)。4 个大脑中动脉和 2 个前交通动脉复杂动脉瘤采用 WEB 植入治疗,6 例(100%)均可行。15 个月的随访显示,改良 Rankin 量表评分与术前相比无变化,且无其他并发症。5 例(83%)有足够的闭塞。
WEB 植入在这种具有挑战性的再治疗情况下提供了一种可行的选择。这是一个小系列,需要前瞻性数据来推断该人群的结果。尽管如此,我们观察到没有并发症和高闭塞率。