Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, Sydney, NSW, Australia.
Endocr Rev. 2020 Jun 1;41(3). doi: 10.1210/endrev/bnaa005.
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.
线粒体损伤被认为是许多非传染性慢性疾病（如心血管疾病、癌症、肥胖症和胰岛素抵抗/2 型糖尿病）的一个主要致病因素。在这里，我们讨论了线粒体在维持细胞和整个机体稳态中的作用、促进线粒体功能障碍的机制，以及这种现象在非传染性慢性疾病中的作用。我们还回顾了与调节线粒体功能和开发当前针对线粒体的治疗方法以治疗非传染性慢性疾病相关的临床前证据的最新进展。最后，我们综合探讨了线粒体损伤如何与这些代谢性疾病有关。
