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A型肉毒杆菌毒素注射至胸大肌和大圆肌与肩胛上神经阻滞治疗偏瘫肩痛的疗效比较:一项前瞻性、双盲、随机、对照试验

Comparison of the efficacy of intramuscular botulinum toxin type-A injection into the pectoralis major and the teres major muscles and suprascapular nerve block for hemiplegic shoulder pain: a prospective, double-blind, randomized, controlled trial.

作者信息

Kasapoğlu-Aksoy Meliha, Aykurt-Karlıbel İlknur, Altan Lale

机构信息

Department of Physical Medicine and Rehabilitation, University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.

Department of Physical Medicine and Rehabilitation, Uludağ University Medicine Faculty, Bursa, Turkey.

出版信息

Neurol Sci. 2020 Aug;41(8):2225-2230. doi: 10.1007/s10072-020-04334-4. Epub 2020 Mar 16.

Abstract

INTRODUCTION

This study aims to investigate the effect of botulinum toxin-A (BoNT-A) injection into pectoralis major and teres major muscles and suprascapular nerve block (SSNB) on pain, range of motion (ROM), and upper extremity function for (hemiplegic shoulder pain) HSP, and to compare the effectiveness of these two methods.

MATERIALS AND METHODS

Sixty patients with HSP were randomly assigned into 2 groups. The Group 1 (n = 30) received BoNT-A injection into the pectoralis major and teres major, and the Group 2 (n = 30) received SSSB. Patients were evaluated just before the start of the study, and 2 and 6 weeks after the start of the study with visual analog scale (VAS), Modified Ashworth Scale (MASH), the passive ROM, and the Fugl-Meyer Scale (FMS) arm section.

RESULTS

In Group 1, statistically significant improvement was found in all evaluation parameters on 2th and 6th week. Group 2 showed significant improvement in all parameters on week 2 (p < 0.05), and significant improvement was observed in MASH and pain in abduction in the 6th week (p < 0.05). When the groups were compared with each other, a statistically significant difference was observed in MASH, ROM, and FMS parameters on week 2 in favor of Group 1; in all evaluation parameters, there was a statistically significant difference in favor of Group 1 on week 6 (p < 0.05).

CONCLUSION

We concluded that BoNT-A injection into the pectoralis major and teres major muscles for HSP was equal in the short term and more effective in the middle term compared with SSNB treatment in improving pain, ROM, and function.

摘要

引言

本研究旨在探讨向胸大肌和大圆肌注射A型肉毒毒素(BoNT-A)以及肩胛上神经阻滞(SSNB)对偏瘫肩痛(HSP)患者的疼痛、活动范围(ROM)和上肢功能的影响,并比较这两种方法的有效性。

材料与方法

60例HSP患者随机分为2组。第1组(n = 30)接受胸大肌和大圆肌BoNT-A注射,第2组(n = 30)接受肩胛上神经阻滞。在研究开始前、开始后2周和6周,采用视觉模拟量表(VAS)、改良Ashworth量表(MASH)、被动活动范围和Fugl-Meyer量表(FMS)上肢部分对患者进行评估。

结果

第1组在第2周和第6周时,所有评估参数均有统计学意义上的显著改善。第2组在第2周时所有参数均有显著改善(p < 0.05),在第6周时MASH和外展疼痛有显著改善(p < 0.05)。两组相互比较时,第2周时MASH、ROM和FMS参数有统计学意义上的显著差异,有利于第1组;在第6周时,所有评估参数均有统计学意义上的显著差异,有利于第1组(p < 0.05)。

结论

我们得出结论,对于HSP患者,向胸大肌和大圆肌注射BoNT-A在短期内与肩胛上神经阻滞治疗效果相当,在中期改善疼痛、ROM和功能方面更有效。

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