Abbott Dawn E E, Allen Andrew L
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Current address: Tudor Glen Veterinary Hospital, St. Albert, Alberta, Canada (Abbott).
J Vet Diagn Invest. 2020 Mar;32(2):329-335. doi: 10.1177/1040638720907659.
We describe and illustrate herein a case of eosinophilic pulmonary granulomatosis (EPG) in a 16-mo-old, castrated male, Great Pyrenees crossbred dog. EPG appears to differ from eosinophilic pneumonias and eosinophilic bronchopneumopathy in dogs by the presence of nodules and masses in the lungs composed of eosinophils, macrophages, and various combinations of lymphocytes, plasma cells, neutrophils, and mast cells within fibrous tissue. Specific information from this dog was added to the information from the limited number of other dogs diagnosed with EPG reported in the veterinary literature, and the information analyzed. EPG appears to have no breed or sex predilection and tends to be a disease of younger dogs, often ≤ 3 y of age. Antemortem imaging of nodules and masses in the lungs, combined with cytologic evidence of eosinophils in the lesions, is highly suggestive of EPG, and the diagnosis can be confirmed postmortem. Concurrent eosinophilia and basophilia can be features of EPG, but their diagnostic value requires further investigation, as does the possible causal association with infection.
我们在此描述并举例说明一只16月龄、已去势的雄性大白熊犬杂交犬患嗜酸性肺肉芽肿病（EPG）的病例。EPG似乎与犬类嗜酸性肺炎和嗜酸性支气管肺炎不同，其肺部存在由嗜酸性粒细胞、巨噬细胞以及纤维组织内淋巴细胞、浆细胞、中性粒细胞和肥大细胞的各种组合构成的结节和肿块。这只犬的具体信息被添加到兽医文献中报道的其他少数几只被诊断为EPG的犬的信息中，并进行了分析。EPG似乎没有品种或性别倾向，且往往是幼龄犬的疾病，通常年龄≤3岁。肺部结节和肿块的生前影像学检查，结合病变中嗜酸性粒细胞的细胞学证据，高度提示EPG，死后可确诊。同时出现嗜酸性粒细胞增多和嗜碱性粒细胞增多可能是EPG的特征，但它们的诊断价值以及与感染可能的因果关系都需要进一步研究。
