Spears Jenna, Chetrit David Alexandre, Manthey Sina, Lee Christopher, Al-Saiegh Yousif
Department of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USA.
Case Rep Rheumatol. 2020 Feb 26;2020:7234069. doi: 10.1155/2020/7234069. eCollection 2020.
Apixaban is a rare cause of leukocytoclastic vasculitis (LCV). To our knowledge, there is only one other reported case due to apixaban in the literature. We present a case of apixaban-induced leukocytoclastic vasculitis in a 95-year-old male. He had been started on apixaban 12 days prior to presentation and developed worsening palpable purpura of his lower extremities. Possible etiologies of this new rash were excluded, with biopsy showing extensive purpura with superficial perivascular neutrophilic infiltrate and leukocytoclasis. Apixaban was discontinued, and the patient was started on a slow prednisone taper with subsequent resolution of his rash.
阿哌沙班是白细胞破碎性血管炎（LCV）的罕见病因。据我们所知，文献中仅有另一例因阿哌沙班导致的病例报道。我们报告一例95岁男性因阿哌沙班诱发的白细胞破碎性血管炎。他在就诊前12天开始服用阿哌沙班，随后出现双下肢可触及的紫癜且逐渐加重。排除了这种新发皮疹的可能病因，活检显示广泛紫癜伴浅表血管周围中性粒细胞浸润及白细胞破碎。停用阿哌沙班后，患者开始缓慢减量使用泼尼松，随后皮疹消退。
